罗格列酮对非酒精性脂肪性肝纤维化肝星状细胞活化与PPARγ、TGFβ1表达地影响.pdfVIP

中文摘要 3罗格列酮干预组小鼠肝组织病理改变明显减轻，证实 罗格列酮具有延缓或阻止脂肪性肝纤维化的作用。干预组 可以通过激活PPAR7而逆转活化的HSCs恢复静息状态，并抑 制TG邓1表达而阻止脂肪性肝纤维化的形成。 关键词：肝纤维化；非酒精性脂肪性肝炎；罗格列酮； 肝星状细胞；过氧化物酶体增生物激活受体丫；转化生长因 子p 英文摘要 Effectof onactivationofHSCsand rosiglitazone of and in expression TGFplfibrosing PPARy nonalcoholicnonalcoholic SteatoneDatltlS steatohepatitis ABSTRACT Objective：Nonalcoholic thebasis of orNASH with NASH associated fibrosing fibrosis，which be fibrosisandcirrhosis．Inthe maycomplicatedbyprogressive of factorstake fibrogenesis progressionfibrosingNASH，many intheactivationof stellate can part hepatic cells(HSCs)that excessiveextracellular product matrix(ECM)．Atpresent，the of NASHisnot pathogenesisfibrosing adequatelyexplored； and thereis evidencethattheactivation growing phenotype of the transdifferentiationstellate hepatic cells(HSCs)werekey and of eventintheformation fibrosis． hepatic progression Peroxisome a pr