大黄金银花复方制剂对小鼠痔疮模型治疗作用的研究.doc

项目编号：2010-DXS-3 商丘师范学院 “大学生创新性实验计划”项目 研究论文（调研报告） 题 目：大黄金银花复方制剂对小鼠痔疮模型治疗作用的研究 项目负责人：_____ 所属单位： _______ 指导教师：____ 所属单位：_______________ 参与学生：____________________________________ 项目执行时间：年_月 至年 月 ABSTRACT: Objective: To investigate the anti-inflammatory、analgestic and hemostatic effect of R hubarb homey suckle compound agent .Method: Animals were divided into five group randomly , including control group、Musk hemorrhoids ointment、Rhubarb homey suckle compound agent、high dose group、middle dose group and low dose group .The anti- inflammatory effect of Rhubarb homey suckle compound agent was observed by using the mouse ear inflammation model induces by xylol. The analgesic effect of Rhubarb homey suckle compound agent was tested by observing the mouse reaction to the pain simulated by heat conduction and chemical stimulus. The bleeding time was tested by adopting mouse tail-cutting method. Result: Rhubarb homey suckle compound agent greatly suppressed the swelling of mouse ear induced by xylol. Rhubarb homey suckle compound agent could relieve the pain stimulated by heat and chemical stimulus. However, it could not significantly shorten the bleeding time. Then we can conclude that : Rhubarb homey suckle compound agent has strong anti- inflammatory、analgestic effect, but the hemostatic effect is not good. KEY WORDS Rhubarb homey suckle compound agent , anti-inflammatory, analgestic, hemostatic 痔疮，是一种常见病和多发病，古有“十人九痔”之说，可见发病率之高。因此，对于痔疮的研究和治疗是一项很有意义的工作[1]。痔疮的病理特征是肛垫病理性肥大、移位及肛周皮下血管丛血流淤滞形成的局部肿块。由于肛门形成静脉血管瘤而致肛周肿胀与血管病变诱发产生出血、疼痛、感染、坠胀、瘙痒等临床症状。除严重内痔和混合痔首选手术外，中轻度患者宜用药物治疗[2]。 大黄是多种蓼科大黄属的多年生植物的合称，也是中药材的名称。在中国地区的文献里，“大黄”指的往往是马蹄大黄。在中国，大黄主要作药用，但在欧洲及中东，他们的大黄往往指另外几个作食用的大黄属品种，茎红色。气清香，味苦而微涩，嚼之粘牙，有砂粒感。秋末茎叶枯萎或次春发芽前采挖。除去细根，刮去外皮，切瓣或段，绳穿成串干燥或直接干燥。中药大黄具有攻积滞、清湿热、泻火、凉血、祛瘀、解毒等功效。金银花，为中药材和植物的统称。植物金银花又名忍冬，为忍冬科多年生半常绿缠绕木质藤本植物。“金银花”一名出自《本草纲目》，由于忍冬花初开为白色，后转为黄色，因此得名金银花。药材金银花为忍冬科忍冬属植物忍冬及同属植物干燥花蕾或带初开的花。金银花自古被誉为清热解毒的良药。它性甘寒气芳香，甘寒清热而不伤胃，芳香透达又可祛邪。金银花既能宣散风热，还善清解血毒，用于各种热性病，如身热、发疹、发斑、