9-监测ABO不相容性肾移植及ABO血型抗体滴度.pptVIP

Streamlining ABO Antibody Titers For Monitoring ABO Incompatible Kidney Transplants Wei Cai, M.T. (ASCP) wcai2@jhmi.edu Johns Hopkins Medical Institution 监测ABO不相容性肾移植的ABO血型抗体滴度约翰 霍伯金斯医学院蔡伟 Background Information Johns Hopkins Hospital Department of Pathology Transfusion Medicine Division Specialist in Blood Bank Technology AABB (American Association of Blood Banks) ABO Incompatible Kidney Transplant Program 背 景 知 识 约翰 霍伯金斯大学医院 病理系 输血医学部 美国血库协会 血库技术专家 ABO 血型不相容性肾移植计划 Crossing the ABO Barrier for Kidney Transplants As of May 25, 2007: 75,711 patients awaiting kidney transplantation In 2006, 17,092 kidney transplants were performed (6,433 or 37.6% living donors): Group O 7,662 A 6,354 B 2,255 AB 821 至2007年5月25日止， 有75,711名病人在等待进行肾移植2006年 进行了17,902个肾移植，其中6,433约37.6%是活体肾移植 血型 肾移植  O 7,662 A 6,354 B 2,255  AB 821  Deaths on Waiting List In 2006, 4,056 patients died waiting for a kidney transplant, or 11.1 patients died per day 2,049 Group O 1,250 Group A 629 Group B 128 Group AB 在等待中死去的病人 2006年，共有4,056名等待肾移植的病人死亡，即每天有11.1名病人在等待中死去。 Cadaveric Kidney Transplant Wait 等待尸肾移植的病人数及等待时间 至07年5月25日 登记 等待 5年或5年以上 所有血型 75,711 8,079 O 39,713 4,459 A 21,457 1,844 B 12,379 1,592 AB 2,162 184 Cadaveric Kidney Transplant Wait If registered in 2001-2002, median wait times as of May 25, 2007 Objectives Expand donor pool and availability of organs for transplantation Decrease time on organ waiting list Circumvent hyperacute rejection and/or AMR (due to ABO and/or HLA antibodies) by developing immunomodulatory protocols ABO incompatible Donor-recipient with positive crossmatches (HL