新型纳米材料用于难溶抗癌药物的靶向输送（Novel nanomaterials for targeted transport of poorly soluble anticancer drugs）.doc

新型纳米材料用于难溶抗癌药物的靶向输送（Novel nanomaterials for targeted transport of poorly soluble anticancer drugs） Novel nanomaterials for targeted transport of poorly soluble anticancer drugs In recent years, researchers have screened a large number of active compounds with high throughput by high throughput screening technology, but most of these compounds have high molecular weight and strong hydrophobicity. According to statistics, at least 40% of the drugs are restricted because of the use of insoluble problems. For example, paclitaxel is one of the most effective broad-spectrum antitumor drugs. But due to its poor water solubility, it is often injected with polyoxyethylene castor oil and ethanol mixture as solvent and then injected intravenously. This route of administration will cause the drug to be distributed throughout the patients body, causing toxic side effects, and the introduction of organic solvents can cause severe allergic reactions. Figure 1. Cellular uptake of PTX after treating A549 cells with different PTX formulations for H 12 (a). The corresponding CLSM images on the right penal showing the uptake of PTXPMNTs without (b) and with (c) a magnetic field. Data represent averages, with error bars being standard deviations from three independent experiments performed in triplicate. Scale bars: 10 m.? In order to solve this problem, Ma Guanghui research group to build a biochemical laboratory transmission system based on magnetic iron oxide nanotubes, the insoluble anticancer drug taxol targeted delivery and efficient delivery. By controlling the crystallization process, paclitaxel nanocrystals can be successfully loaded inside the nanotube. Hydrophilic molecules in the system can not only help to avoid identification of surface modification of the reticuloendothelial system, has a long circulating half-life in vivo; but also can show good magnetic targeting under magnetic field, improve the quality of drug uptake in tumor cells; the nanotubes will be taken up by t