三七药理活性研究（37 pharmacological activity study）.docVIP

三七药理活性研究（37 pharmacological activity study） Advances in pharmacological activities of total saponins of 37 Brief summary: 37 total saponins (PNS) in 37, the content is as high as 12.001% or so, contains a variety of monomer saponins. Modern pharmacological studies show that PNS has many therapeutic targets, and has obvious pharmacological activity in anti-inflammatory, anti-tumor and anti renal interstitial fibrosis, and has been widely used in the treatment of ischemic cardiovascular and cerebrovascular diseases. In this paper, we reviewed the research progress of pharmacological activities of PNS in the last 3 years, aiming to provide basic data for future research and utilization of PNS. 1: protective effect on cerebral ischemic injury. Pharmaceutical thesis templates 2: cerebral ischemia reperfusion injury (CIRI) is more obvious, more serious damage and dysfunction than ischemia before reperfusion. Tang Yinghong found that after cerebral ischemia / reperfusion through activation of matrix metalloproteinase -9 (MMP-9), induced by extracellular matrix (ECM) damage, leading to neuronal damage, PNS can inhibit cerebral ischemia and MMP-9 reperfusion brain tissue expression, enhancement of matrix metalloproteinase inhibition of -l (TIMP-1) expression, significantly improve cerebral ischemia then the survival rate of neurons in the brain tissue, reduce cerebral ischemic injury. 3: anti hypoxic brain injury, hypoxic-ischemic brain damage and neuronal apoptosis and related gene regulation have attracted more and more attention. Many kinds of genes are induced after cerebral ischemia and hypoxia. Some of them can promote apoptosis, while others can inhibit apoptosis. In the anti apoptosis gene, the important role of the Bcl-2 family has been recognized, it plays an important role in the inhibition of cell death in the central nervous system, in neurons by external stimulation can protect cells from apoptosis. PNS may inhibit the apoptosis induced by hypoxia / reoxygenati