妥泰（Topiramate）.docVIP

妥泰（Topiramate） Topiramate tablets Topamax [manufacturer] Xian-Janssen [traits] The chemical name of topiramate is 2,3:4,5- double -0- (1- methyl ethyl) - beta -D, C12, H21, NO8S, with a molecular weight of 339.36. Topiramate is a white crystalline powder, which has a bitter taste, is easily soluble in sodium hydroxide or sodium phosphate, and has an alkaline solution of pH value of 9-10. It is soluble in acetone, chloroform, two methylene sulfoxide and ethanol. The solubility in water is 9.8 mg/mL, and the pH value of its saturated solution is 6.3. This is a round coated sheet with embossed lines with the following specifications and colors: 25 mg: white, one with TOP, and the other with 25. 50 mg: pale yellow, with one side engraved with TOP, and the other with 50. 100 mg: yellow, with TOP engraved on one side and 100 on the other. [pharmacological effects] Topiramate is a new antiepileptic drug which is substituted by amino sulfonic acid ester. Electrophysiological and biochemical studies in cultured neurons revealed three characteristics of topiramate related to its antiepileptic effects. The action potential that was repeatedly stimulated by continued depolarization of neurons was blocked in a time-dependent manner by topiramate: showed that topiramate blocked the state dependent sodium channel. Topiramate can increase the frequency of gamma aminobutyric acid (GABA) and activation of GABA receptors, thereby enhancing the ability of GABA to induce chloride influx: demonstrating that topiramate can enhance inhibitory neurotransmitter action. Since the antiepileptic properties of topiramate are markedly different from that of phenylpropanoid two, it may be a GABA receptor subtype that regulates phenylpropanoid two nitrogen insensitivity. Topiramate can antagonize kainic acid (Kainate) activation of excitatory amino acid (glutamic acid) subtype Kainate/AMPA, but the N- methyl -D- aspartate (NMDA) had no significant effect on the NMDA receptor subtype. The above effe