环磷酰胺致肝损伤时肝细胞线粒体的变化-江苏大学.PDF

18 1 ( ) V o.l 18 N o. 1 2008 1 Journa l o f J iangsu U n ive rsity( M ed icine Ed ition) Jan. 200 8 张海峰, 高 静, 林 娜, 夏 明 ( , 2 120 13 ) ] : ( CP ) : ICR 100, - 1 - 1 150, 200 mg# kg # d CP, 5 d, 7 ( ALT ) (M DA ) ( SOD ) ( GSH ) , , ( RT-PCR ) ( voltage-dependent an ion channel, VDA C) : ALT , CP SOD G SH , M DA CP, , RT-PCR , CP VDA C, CP : CP , VDAC ] ; ; ; ; ] R 99 ] A ] 1671- 7783( 200 8) 0 1- 00 19- 04 Alteration ofmitochondria in hepatocyte during hepatotoxicity induced by cyclophospham ide ZHANG H a i-f eng, GA O J ing, LIN N a, X IA M ing ( School of Pharm aceu tical Science, Jiangsu U n iversity, Zhenjiang Jiangsu 2 120 13, Ch in a) [Abstract] Objective: Study the hepatotox icity induced by cyclophospham ide( CP ) and its possib le m -i tochondrial m echan ism s. Methods: T he alan ine am ino transferase ( ALT ) activ ity in serum, and m alond ia-l dehyde( MDA ) , glutath ione ( GSH ) and superox ide d ism utase ( SOD) in liver were determ ined on the 7 th - 1 - 1 day after the last adm in istration o f 100, 150 and 200 m g# kg # d CP for 5 days intraperitonea lly. Both the m em b