大豆多肽对过度训练大鼠肠道免疫功能的影响-天津体育学院学报.PDFVIP

天津体育学院学报 2009 年第24 卷第3 期 Journal of TUS Vol．24 No．3 2009 209～2 11 ● 成果报告 Original Articles 大豆多肽对过度训练大鼠肠道免疫功能的影响 1 2 3 唐智明 ，王海军 ，金其贯 摘要：目的：建立过度训练大鼠模型，探讨大豆多肽对过度训练大鼠肠道免疫功能的干预作用。方法：将大鼠随机分为对照组（C）、过度训练 组（OT）和大豆多肽干预组（OS）。检测各组大鼠小肠组织SIgA、Gln 的含量以及小肠CD4+ 、CD8+T 细胞数量。结果：与对照组比较，过度训练 组大鼠小肠组织中SIgA 和Gln 含量显著下降，CD4+T 细胞数量 、CD4+/CD8+ 比值显著下降，小肠CD8+T 细胞数量显著升高；与OT 组相比， CD4+ T 细胞数量、CD4+/CD8+ 的比值显著升高，CD8+T 细胞的数量显著降低。结论：过度训练导致大鼠肠道免疫功能显著下降，过度训练时 大鼠小肠Gln 水平下降，可能是过度训练引起肠道免疫功能降低的主要机制。补充大豆多肽可显著改善长期大负荷运动训练大鼠肠道免疫 功能，其确切机制还有待进一步深入研究。 关键词：过度训练；大豆多肽；肠道免疫功能 中图分类号：G 804.23 文献标识码：A 文章编号：1005- 0000 （2009）03- 0209- 03 Effect of Soybean Peptide Supplementation on the Intestinal Immune Function of Overtraining Rats 1 2 3 TANG Zhiming , WANG Haijun , JIN Qiguan (1.School of Sports Science, Nantong University, Nantong 226007, China; 2.Nantong Shipping College, Nantong 226010, China; 3.School of PE, Yangzhou University, Yangzhou 225009, China) Abstract: Objective: To establish rat model for overtraining and explore the intervention effect of soybean peptide supplementation on the intestinal immune function of overtraining rats and its mechanism. Method: Experimental rats were randomly divided into control group, overtraining group, and soybean pep － tide intervention group. The content of Gln, sIgA and CD4+, CD8+ quantity in small intestine were examined. Results: Compared with the control group, in the small intestine tissue of overtraining group, sIgA, Gln content, CD4+ quantity and the CD4+/CD8+ ratio obviously decreased, CD8+ quantity obviously increased. Compared with the overtraining group, in the small intestine of OS group, sIgA and Gln had a trend of increasing, but had no significant differ － ence, but CD4+ quantity, CD4+/CD8+ ratio increased significantly, CD8+ quantity obviously reduced. Conclusion: Overtraining mi