149例疑为药物过量患者血中苯二氮(艹卓)类药物浓度测定.pdfVIP

149例疑为药物过量患者血中苯二氮革类药物浓度测定 吴建龙+，何英，钱文碌，陈小燕，宋少刚，杨径(深圳市第二人民医院，深圳市518035) A 1001 074203 中图分类号 R927．2；R971+．3文献标识码 文章编号 0408(2004)12 摘要 BZDs血药浓度对临床厦时诊断和治疗有一定参考价值，但其浓度高低与患者病情的轻重并无珏然联系。 关键词 药物过量；苯二氮革类药物；荧光偏振免疫法 Serum in149CasesofUnconfirmedOverdose Detectionof Concentrations Benzodiazepines Drug wu Jianlong，HEYing，Q1ANWenjing，CHENXiaoyan，SONGShaogang，YANG 518035) People’SHospital，Shenzhen ABSTRACT findthe detectionmethodforserum OBJECTIVE：Toquick benzodiazepines of 149 who flurosence methodtOdetecttheserumconcentration patients polarizationimmunoassay resultsln104 from149 were of overdosein unit．RESULTS：We samples pa— suspiciousreceivingdrug emergency gotpositive thestateof tients．butthe1evelsofBZDsconcentrationwerenotcoincidentwith drug useful withunconfirmedoverdosein cautionshould usedinour isa and for emergencyunit，but reportquick assaypatients drug result to betakeninthe doctors． interpretation KEYWoRDS drugoverdose：benzodiazepines：flurosencepolarization 药动学参数详见表2。 3．2 药动学参数的分析 表2 受试制剂与参比制剂的药动学参数(i±s) Tab2 The of 0．7)h，与SaroltaB等…报道结果相似，与赵磊等“】报道结果 pharmacokinetieparametersgemfibrozil aftertwo l po preparations(±s B等01和陈得光等…报道结果均有差 叁塑 堂亟型型 叁些型型 道结果相似，与Saroha