40例使用替加环素的临床用药分析.pdfVIP

·80 · Herald of Medicine Vol．36 No．1January2017 ·用药指南· 40例使用替加环素的临床用药分析∗ 叶伟红,应小飞,傅军霞,郭晶晶,徐艳艳,田伟强 (浙江省丽水市中心医院药学部,丽水　 323000) 摘　 要　 目的　 评价使用替加环素的住院患者临床用药情况。 方法　 采用回顾性研究方法,收集浙江省丽水市中 心医院2012年1月-2014年12 月使用替加环素住院患者的临床资料(基础疾病、细菌学培养结果、联合用药、疗效、不 良反应发生情况等),共40例,并对其应用进行合理性评价。 结果　 该院近3年使用替加环素患者的抗感染治疗有效率 为42.5%,合理使用率17.5%,基本合理使用率77.5%,不合理使用率5.0%,出现不良反应6 例(15.0%)。 结论　 该院 住院患者替加环素的使用基本合理;替加环素对各类敏感菌引起的感染临床疗效较好,但不良反应发生率较高,临床应 用过程中应引起关注。 关键词　 替加环素;药物不良反应;用药分析 中图分类号　 R978;R969.3　 　 　 文献标识码　 B　 　 　 文章编号　 1004-0781(2017)01-0080-04 DOI　 10.3870/ j.issn.1004-0781.2017.01.020 Analysis of Clinical Use of Tigecycline in40 Cases YE Weihong, YING Xiaofei, FU Junxia, GUO Jingjing, XU Yanyan, TIAN Weiqiang (Department of Pharmacy,Lishui Central Hospital,Zhejiang Province,Lishui323000,China) ABSTRACT　 Objective　 To evaluate clinical use of tigecycline in hospital patients. 　 Methods　 Basic diseases, pathologic examinations,concurrent medication,therapeutic efficacy and side effects of40 patients in Lishui Central Hospital of Zhejiang ProvincefromJanuary2012 to December2014 were analyzed retrospectively.　 Results　 The effective rate of patients using tigecycline for anti-infection treatment in hospital was 42.5%. The rates of rational use, basically rational use and irrational use were 17.5%,77.5% and 5.0%,respectively. Adverse drug reactions occurred in 6 cases of tigecycline use (15.0%).　 Conclusion　 Clinicaluseoftigecyclineininpatientswasbasicallyreasonableinthishospital. Theclinicalcurative effect of tigecycline was good in a variety of infections caused by sensitive bacteria. However,the incidence of adverse drug reactionswas high. Attentions should be paid in clinical application. KEY WORDS　 Tigecycline;Adverse drug reactions;Drug analys