帕金森病运动并发症发生机制的研究进展.pdfVIP

· 656 · 中国现代神经疾病杂志2013年8月第13卷第8期 ChinJContempNeurolNeurosurg,August 2013,Vol. 13,No. 8 ·专题讲座· 帕金森病运动并发症发生机制的研究进展 熊念 孙圣刚 【摘要】 帕金森病是临床常见的中枢神经系统变性疾病，拟多巴胺类药物仍是其主要治疗手段。 帕金森病患者长期接受多巴胺替代治疗后，可出现运动并发症，发生机制目前尚未完全阐明，而且对有 些运动并发症仍缺乏有效的治疗方法，给帕金森病的治疗带来了困难和挑战。近年来，国内外学者对帕 金森运动并发症的发生机制进行了广泛的研究，取得了显著进展，本文拟从左旋多巴药代动力学及药效 学、神经生化学等角度阐述导致运动并发症的相关机制，以期为后续帕金森运动并发症的机制及治疗相 关研究提供新视野。 【关键词】 帕金森病； 运动障碍； 左旋多巴； 综述 ThepotentialmechanismsformotorcomplicationsofParkinsonsdisease XIONGNian,SUNSheng⁃gang Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan430022,Hubei,China Correspondingauthor:SUNSheng⁃gang(Email:sunshenggang@126.com) 【Abstract】 Parkinsons disease (PD) is a common neurodegenerative disease. Dopaminergic replacement therapy is still considered as a major treatment for PD. However, long⁃term dopaminergic replacementtherapyforPDpatientsisfrequentlyassociatedwiththedevelopmentofmotorcomplications. To date, the mechanisms underlying motor complications have not been completely understood yet. Moreover,partsofmotorcomplicationsarelackoftherapeuticalternatives. Allthesecharactersmakethis disorder difficult and challenging to manage. Increasing number of researches have been proposed in recentyearsforelucidatingtheunderlyingmechanismsoflevodopa⁃relatedmotorcomplications,resultingin muchprogression. Forbetterunderstandingthemanagementofmotorcomplications,hereweprovidean overview of the current knowledge of the potential mechanisms, including the pharmacodynamic and pharmacokineticmechanismsoflevodopaandlevodopa⁃associatedneurotransmittersystems. 【Keywords】 Parkinson disease; Movementdisorders; Levodopa; Review This studywassupportedbytheNationalNaturalScienceFoundationofChina(No.. 帕金森病（PD）是目前临床公认的第二大中枢 运动并发症的发生与进展似乎很难用某一因素解 神经系统变性疾病。尽管