亚临床甲状腺功能减退症孕期筛查及意义.pdfVIP

中国现代医生 2015年7月第53卷第21期 窑妇幼医学 窑 亚临床甲状腺功能减退症孕期筛查及意义 林 敏 钱小泉银 郑建红 浙江省乐清市妇幼保健院保健科袁浙江乐清 325600 [摘要] 目的了解乐清市妊娠期亚临床甲状腺功能减退症发病率袁评价综合干预效果袁为开展常规筛查提供依据遥 方法2013年1月耀2014年1月对1028例孕周约20周单胎孕妇进行血清TSH尧FT4尧TPOAb 甲状腺功能筛查遥 结果 异常 141例袁检出率为 13.72%袁其中亚临床甲减58例袁临床甲减21例袁低甲状腺素血症33例袁甲亢9例袁单纯甲 状腺过氧化物酶抗体渊TPOAb冤阳性20例曰亚临床甲减组中袁TPOAb 阳性27.59%渊16/58冤袁外来人口占29.31%渊17/ 58冤袁平均年龄渊28.72依4.22冤岁袁甲状腺功能正常组TPOAb 阳性2.25%渊20/887冤袁外来人口占 14.32渊127/887冤袁组间 比较差异有统计学意义渊P约0.05冤遥 针对筛查结果袁对不同组别分别采取不同干预措施袁并对亚临床甲减组重点跟 踪随访评估效果袁干预后临床甲减2例袁占1.42%袁亚临床甲减 10例袁占7.09%袁低T4血症6例袁占4.26%遥 结论 孕期甲状腺功能异常率较高袁尤其亚临床甲状腺功能减退症占比最大袁不容忽视遥 予以筛查并早期干预袁可以有 效减少并发症及出生缺陷的发生遥 [关键词] 亚临床甲状腺功能减退症曰孕期检查曰筛查曰临床干预曰出生缺陷 [中图分类号] R714.2 [文献标识码] B [文章编号] 1673-9701渊2015冤21-0045-03 Hypothyroidism screening during pregnancy and significance of subclini鄄 calthyroidfunction LIN Min QIANXiaoquan ZHENG Jianhong Departmentof Health, Maternaland Child Health HospitalofYueqing inZhejiang Province,Yueqing 325600,China [Abstract] Objective To observe the pregnancy period of subclinical thyroid dysfunction disease incidence rate in Yueqing City, evaluation effect of comprehensive intervention and provide the basis for carrying out routine screening. Methods All of 1028 cases of gestational age20 weeks gestation pregnant women from January 2013 to January 2014 were collected, serum TSH, FT4 and TPOAb in thyroid function screening were all screened. Results 141 cases were abnormal,the detectionrate of 13.72%,There were 58 casesof subclinicalhypothyroidismamongthem, and subclinical hypothyroidism in 21 cases, 33 cases of hypothyroidism, 9 cases of hyperthyroidism,simple thyroid peroxi鄄 dase antibody(TPOAb)positive 20 cases; Subclinicalhypothyroidism group, TPO