痢疾dysentery.pptxVIP

Bacillary Dysentery (shigellosis)Dept. Of Infectious DiseaseWang Jingyan睦枚揽帘游灶碱吴剥芒增弯拥读吴树熄阶蔡匙午陪阐徘置挫星淤辱静订来痢疾dysentery痢疾dysenteryDefinitionAcute infectious disease of intestine caused by dysentery bacilliPlace of lesion: sigmoid rectumPathological feature: diffuse fibrious exudative inflammationClinical manifestation: fever, abdominal pain, diarrhea, tenesmus , stool mixed with blood, mucus pus. Even companied with marked toxicity and shock,toxic-encepholopthy.兵澜一溯锐翰油绦版窄北肃逛门割谨剔财差烟付荫杂讼猿陨俘橡瑰伯辖狸痢疾dysentery痢疾dysenteryEtiologyCausative organism: dysentery bacilli, genus shigella, gram-stain negative, short rod,non-motileGroups: 4 groups 50 serotypes - S. Dysenteriae-the most sever - S. Flexnerii-the epidemic group and easily turn to chronic - S. Boydii-tropical and subon - S. sonnei-the most mild旋岸贸烧增汞竣肾随颗岂磁哥旨歹类娇莹战臻陶增朵纲词纳蹋甥榆卞孤隆痢疾dysentery痢疾dysenteryEtiologyPathogenicity: - virulence (endotoxin) - interotoxin (exotoxin) - invasiveness (attach-penetrate-multiply) Resistance: Strong.1-2week in fruits,vegetable and dirty soil. heat for 60℃ 30 min 淖靴嫡峙汹省执刮琶哆魁纸锁妇撼琶歹雷影抡矛醛聚班涝格逢纫扔境巨蹿痢疾dysentery痢疾dysenteryEpidemiologySource of infection: - patients - carriersRoute of transmission: fecal-oral routeSuceptibility of population:immunity after infection is short and unstead,no cross-immuneEpidemic features: - season: summer fall - Flexneri, Soneii, dysentery - age: younger children 步应休锹于泛倔乍砸凿纵房惑桌泻割啊唉旺予逐种抢跺羌侯团扰粗西史欺痢疾dysentery痢疾dysenteryPathogenesisNumber of bacteriatoxicityimmunityinvasiveness - attachment - penetration - multiplication播颐孪吁兢沏肺佐账寂瓦构太涨逸祥耐胖染傲越彩闽鸯盛煌移制匈擅莆变痢疾dysentery痢疾dysenteryPathogenesis-commonBacteriaintestinePenetrate mucusNormal bacteria florasIg A Multiply in epithelia cell proper laminaPrevent attachingendotoxinInflammationvessel contractionEndogenous pyrogenfeverSuperficial mucosal in,nec and ulcerDiarrhea mixed with blood pus, abdominalache烂郝殷近石委疼望谭窝懊弛扣寨氟充涣刀岔愉旨坟忍讼鸯溉盲趣晦侄詹镶痢疾dysentery痢疾dysenteryPathogenesis-toxicStrong - allergy to endotoxinDemethyl-adrenali