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PK/PD
O
Study on Nonlinear PK/PD Model and
Discussion of Parameter Estimation Method
A Thesis Submitted to Chongqing University
in Partial Fulfillment of the Requirement for the
Master’s Degree of Science
By
Cao Li
Supervised by Ass. Prof. Guanghui Huang
Specialty:Probability and Mathematical Statistics
College of Mathematics and Statistics of Chongqing
University, Chongqing, China
April, 2013
“”
ODEs(PK/PD)
PK/PD
SDE
(DMF)
(EKF)
(DMF)EKF
2000
I
ABSTRACT
Pharmacokinetic is a science to deal with the dynamic process of drug in the body
using mathematical analysis method, has important theoretical value and is an
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