脑蛛网的膜下腔出血.pptVIP

Subarachnoid Hemorrhage Causes Microcirculation Deficit：an in-vivo microscopy study Chen Nishan / 陈妮姗 Outline Introduction; Research purposes; Material and method; Result and Discussion; Evaluation and outlook; Conclusion. References Cahill W J, Calvert J H, Z Hang JH, et al. Mechanisms of early brain injury after subarachnoid hemorrhage [ J ] . J Cereb Blood Flow Metab, 2006, 26( 11) : 1341-1353 E. Ko?niewska, R. Michalik et al. Mechanisms of vascular dysfunction after subarachnoid hemorrhage [J]. J. Physiology and Pharmacology, 2006, 57, 11, 145.160 Westerm Aier T, Jauss a, Eriskat J, et al. Time-course of cerebral perfusion and tissue oxygenation in the first 6 h after experimental subarachnoid hemorrhage in rats [ J ] . J Cereb Blood Flow Metab, 2009, 29( 4) : 771-779 Benjamin Friedrich, et al. Experimental subarachnoid hemorrhage causes early and long-lasting microarterial constriction and microthrombosis: an in-vivo microscopy study. J C ereb Flow Metab.2012, 32(3): 447-455 Ishikawa Mami; Kusaka Gen; Yamaguchi Noriyuki. Platelet and leukocyte adhesion in the microvascularture at the cerebral surface immediately after subarachnoid hemorrhage, J. Neurosurgery, 2009, 64(3): 546-553 Daniel Z, Muhammad F. et al. Delayed ischemia after subarachnoid hemorrhage: result of vasospasm alone or a broader [J], J. Vasc Med 2007 12: 243 Introduction Subarachnoid Hemorrhage (SAH): A subtype of stroke with a particularly high morbidity and mortality. Early Brain Injury (EBI): Occurs within 72h after the initial bleed; No effective treatment is available; Mechanisms have recently started to be understood. Research purposes Material and Method CWp model; Cranial window; Intravital fluorescence microscopy. Result-1 Microvascular Constriction: Numerous constricted arterioles were observed, in contract to venules; Distribution of severity changed over time. Result 1 Microvascular Constriction: Numerous constricted arter