Wistar大鼠的自发肿瘤病变及其发生率.docxVIP

Wistar大鼠的自发肿瘤病变及其发生率徐艳峰1，侯粉霞*2，杨慧芳2，徐玉环1(1．中国医学科学院医学实验动物研究所，卫生部人类疾病比较医学重点实验室，国家中医药管理局人类疾病动物模型三级实验室，北京100021；2．中国疾病预防控制中心职业卫生与中毒控制所，北京100050)【摘要】目的了解Wistar大鼠的各种自发性肿瘤病变及其发生率。方法致癌试验中的对照组，采用4周龄SPF级Wistar大鼠，雌、雄性大鼠各60只，试验前观察1周，常规饲料喂饲104周后处死，进行组织病理学检查。结果报告了Wistar大鼠的各种自发性肿瘤病变及其发生率。雄性大鼠中发生肿瘤的动物占49.12%，发生良性肿瘤的动物占38.60%、发生恶性肿瘤的动物占17.54%；良性肿瘤主要有垂体腺瘤（19.30%）、睾丸间质细胞瘤（5.26%）和皮下纤维瘤（5.26%）；恶性肿瘤主要有鳞状细胞癌（7.02%）和淋巴造血系统肿瘤（3.51%）。雌性大鼠中发生肿瘤的动物占60.34%；发生良性肿瘤的动物占50.00%、发生恶性肿瘤的动物占15.52%；良性肿瘤主要有乳腺纤维腺瘤（25.86%）和垂体腺瘤（24.14%）；恶性肿瘤主要有腺癌（5.17%）和乳腺癌（3.45%）。结论本文报告的Wistar大鼠自发肿瘤及其发生率进一步丰富了现有SPF级Wistar大鼠自发性肿瘤的数据资料，可为有关技术人员提供一定的参考和借鉴。【关键词】Wistar大鼠；致癌试验；自发性肿瘤病变Spontaneousneoplasticlesions of Wistarratsand their incidenceXU Yan-feng1，HOU Fen-Xia2, YANG Hui-fang2，XU Yu-huan1(1. Institute of Laboratory Animal Sciences,Key Laboratory of Human Disease Comparative Medicine, Ministry of Health, Key Laboratory of Human Disease Animal Models, State Administration of Traditional Chinese Medicine,Beijing 100021，China;2. National Institute of Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing 100050)【Abstract】? Objective? To investigate thespontaneousneoplasticlesionsand their incidences in rats. Methods?Sixty male and 60 female specific pathogen-free Wistar rats (4-weeks old ) were used in this study. The rats were acclimated for 1 week prior to initiation of the experiment. They were fed with conventionalfeed for 104 weeksand then sacrificedfor histopathological examination.Results Various neoplastic lesions of the rats and their incidences were analyzed and reported. For male rats, their total tumor incidence was 49.12%, the benign tumor incidence was38.60% and the malignant tumor incidence was 17.54%; The benign neoplastic lesions mainly were pituitary adenoma(19.30%) ,the testisLeydig cell tumor(5.26%) and subcutaneous fibroma (5.26%); The malignant neoplastic lesions mainly were squamous cell carcinoma (7.02%) and lymphoid hematopoietic system tumors (3.51%). Fo