MR医学影像文献Li-2016-Differential neurometabolite alteratio.pdfVIP

Received: 5 March 2016    Accepted: 30 September 2016 | DOI: 10.1111/bdi.12445 O R I G I N A L A R T I C L E Differential neurometabolite alterations in brains of medication- free individuals with bipolar disorder and those with unipolar depression: a two- dimensional proton magnetic resonance spectroscopy study 1,2,a 1,a 1 2 1 Hui Li   | Haiyun Xu   | Yinnan Zhang   | Jitian Guan   | Jie Zhang   |  1 2 1 1 1 Chongtao Xu   | Zhiwei Shen   | Bo Xiao   | Chunlian Liang   | Kaiyuan Chen   |  1 2,3 Jinling Zhang   | Renhua Wu 1Mental Health Center, Shantou University Medical College, Shantou, China Objectives: Bipolar disorder (BD) is a mental disorder characterized by periods of el- 2Department of Medical Imaging, The 2nd evated mood and depression. Many individuals with BD are initially misdiagnosed and Affiliated Hospital, Shantou University treated for unipolar depression (UD). In this study, we report direct comparisons be- Medical College, Shantou, China tween medication- free individuals with BD and those with UD in terms of the neuro- 3The Provincial Key Laboratory of Medical Molecular Imaging, Shantou, China metabolites in the anterior cingulate cortex (ACC), medial prefrontal cortex (mPFC), parietal cortex (PC), and posterior cingulate cortex (PCC) of the brain. Correspondence Renhua Wu, Department of Medical Methods: Participants included medication- free patients with BD or UD, and matched Imaging,