MR医学影像文献Li-2016-CEST theranostics_ label-free MR imagi.pdfVIP

/oncotarget/ Oncotarget, Vol. 7, No. 6 CEST theranostics: label-free MR imaging of anticancer drugs Yuguo Li1,2,*, Hanwei Chen2,3,4,*, Jiadi Xu1,2, Nirbhay N. Yadav1,2, Kannie W. Y. 1,2 4 1,2 5 Chan , Liangping Luo , Michael T. McMahon , Bert Vogelstein , Peter C.M. van 1,2 5 1,2 Zijl , Shibin Zhou and Guanshu Liu 1 F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland, USA 2 The Russell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA 3 Department of Radiology, Panyu Central Hospital, Guangzhou, China 4 Department of Radiology, The First Affiliated Hospital of Jinan University, Guangzhou, China 5 Ludwig Center, Howard Hughes Medical Institute and Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA * These authors have contributed equally to this work Correspondence to: Guanshu Liu, email: guanshu@ Keywords: CEST, MRI, theranostics, image-guided drug delivery, chemotherapy Received: November 01, 2015 Accepted: January 28, 2016 Published: February 02, 2016 ABSTRACT Image-guided drug delivery is of great clinical interest. Here, we explored a direct way, namely CEST theranostics, to detect diamagnetic anticancer drugs simply through their inherent Chemical Exchange Saturation Transfer (CEST) MRI signal, and demonstrated its application in image-guided drug delivery of nanoparticulate chemo