MR医学影像文献Xie-2016-DANTE-Prepared Three-Dimensional FLAS.pdfVIP

ORIGINAL RESEARCH DANTE-Prepared Three-Dimensional FLASH: A Fast Isotropic-Resolution MR Approach to Morphological Evaluation of the Peripheral Arterial Wall at 3 Tesla Guoxi Xie, PhD,1,2 Nan Zhang, MD,3 Yibin Xie, MS,2 Christopher Nguyen, MS,2 Zixin Deng, MS,2 Xiaoming Bi, PhD,4 Zhanming Fan, PhD,3 Xin Liu, MD,1 2 2 Debiao Li, PhD, and Zhaoyang Fan, PhD * Background: To develop and assess a sequence using DANTE dark-blood preparation combined with FLASH readout (DANTE-FLASH) for rapid isotropic-resolution three-dimensional (3D) peripheral vessel wall imaging at 3 Tesla (T). Methods: Numerical simulations were first conducted to optimize imaging parameters for maximizing the wall-lumen contrast. The sequence, implemented at 3T, was then assessed in the bilateral superficial femoral arteries of eight healthy volunteers and three patients who were undergoing non–contrast-enhanced MRA due to known peripheral artery disease. Conventional 2D dark-blood turbo spin echo (DB-TSE) was performed as a reference in all subjects. Image quality on a 5-point scale, apparent wall signal-to-noise ratio, apparent wall-lumen contrast-to-noise ratio, wall thickness, wall area and lumen area were assessed or measured in all healthy subjects. Additionally, the agreement in the depiction of wall thickening or luminal stenosis between DANTE-FLASH and DB-TSE, or MRA was assessed using a 4-point scale in the patient study. Results: DANTE-FLASH allowed for a 30-cm-long coverage within 4 min, whereas DB-TSE took approximately 7 min for a 9-cm-long coverage. Good image quality was obt