MR医学影像文献Zhou-2016-Early evaluation of irradiated parot.pdfVIP

Zhou et al. BMC Cancer (2016) 16:865 DOI 10.1186/s12885-016-2900-2 RESEARCH ARTICLE Open Access Early evaluation of irradiated parotid glands with intravoxel incoherent motion MR imaging: correlation with dynamic contrast- enhanced MR imaging 1† 1† 1 1 1 2 2 3 4 Nan Zhou , Chen Chu , Xin Dou , Ming Li , Song Liu , Lijing Zhu , Baorui Liu , Tingting Guo , Weibo Chen , Jian He1*, Jing Yan2*, Zhengyang Zhou1*, Xiaofeng Yang5 and Tian Liu5 Abstract Background: Radiation-induced parotid damage is one of the most common complications in patients with nasopharyngeal carcinoma (NPC) undergoing radiotherapy (RT). Intravoxel incoherent motion (IVIM) magnetic resonance (MR) imaging has been reported for evaluating irradiated parotid damage. However, the changes of IVIM perfusion-related parameters in irradiated parotid glands have not been confirmed by conventional perfusion measurements obtained from dynamic contrast-enhanced (DCE) MR imaging. The purposes of this study were to monitor radiation-induced parotid damage using IVIM and DCE MR imaging and to investigate the correlations between changes of these MR parameters. Methods: Eighteen NPC patients underwent bilateral parotid T1-weighted, IVIM and DCE MR imaging pre-RT (2 weeks before RT) and post-RT (4 weeks after RT). Parotid volume; IVIM MR parameters, including apparent diffusion coefficient (ADC), pure diffusion coefficient (D), pseudo-diffusion coefficient (D*), and perfusion fraction (f); and DCE MR parameters, including maximum relative enhancement (MRE), time to peak (TTP), Wash in Rate, and the degree of xerostomia were recorded. Correlations of parotid MR parameters with mean radiation dose, atrophy rate and xerostomia de