致病菌生物被膜形成的调节机制及潜在的药物靶标-药学学报.pdfVIP

药学学报 Acta Pharmaceutica Sinica 2012, 47 (2) : 135 143 ·135 · ·综述· 致病菌生物被膜形成的调节机制及潜在的药物靶标 石廷玉, 邓万燕, 谢建平* (西南大学生命科学学院现代生物医 研究所, 三峡库区生态环境和生物资源国家重点实验室培育基地, 重庆 4007 15) 摘要: 自然界的细菌群落往往形成生物被膜。生物被膜的形成是一个连续而复杂的过程, 受到多种因素的调 控。现在研究得比较清楚的是细菌双组分系统和群体感应系统。生物被膜对多种病原菌的毒力有重要影响。因 此, 对细菌生物被膜形成过程中的关键因子设计药物具有重要意义, 可能发现全新的治疗方法。 关键词: 生物被膜; 双组分系统; 群体感应; 药物靶标 中图分类号: R963 文献标识码:A 文章编号: 05 13-4870 (2012) 02-0135-09 Regulatory mechanism underlying pathogen biofilm formation and potential drug targets * SHI Ting-yu, DENG Wan-yan, XIE Jian-ping (Institute of Modern Biopha rmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, School of Lif e Sciences, Southwest University, Chongqing 400715, China) Abstract: Bacterial communities usually develop biofilms abound in nature niche. The development of biofilm is a highly dynamic and complex process coordinated by multiple mechanisms, of which two-component system and quorum sensing are two well-defined systems. Biofilm is involved in the virulence of many pathogens. Therefore, targeting the key factors involved in the biofilm formation represents a novel and promising avenue for developing better antibiotics. Key words: biofilm; two-component system; quorum sensing; drug target 生物被膜 (biofilm, 也称生物膜) 是细菌为适应 式之间转换的调节是非常精细和复杂的, 对其机制 环境而吸附到固体表面的一种生活方式, 其成分包 的了解有助于我们认识细菌适应环境和产生致病性 括细菌和其分泌的疏水多聚基质。细菌的这种生活方 的理论和现实意义。 式却给人类的健康带来了巨大的危害, 其中包括致 生物被膜的形成起始于浮游细胞吸附到固体