天然产物通过细胞自噬调节抑制癌症的研究进展-食品科学.pdfVIP

※专题论述 食品科学 2014, Vol.35, No.23 331 天然产物通过细胞自噬调节抑制癌症的研究进展 1,2 1 1 3,* 张淑芳 ，王玉芳，袁 红 ，陈 宁 （1.武汉体育学院研究生院，湖北 武汉 430079 ；2.武汉体育学院体育科技学院，湖北 武汉 430205 ； 3.武汉体育学院健康科学学院，运动干预与健康促进湖北省协同创新中心，湖北 武汉 430079 ） 摘  要：传统的化疗手段在抑制肿瘤细胞生长的同时也会损伤到正常细胞，所以其临床治疗效果受到很大限制。新 型天然产物抗癌化合物基于其安全性和有效性，将会成为人工合成化合物的替代物。临床前和临床研究已经证实一 些植物天然产物（如白藜芦醇、姜黄素、人参皂苷等）具有抗癌潜力。本文综述具有代表性的天然产物如何通过靶 向细胞内自噬通路诱导肿瘤细胞死亡及其涉及到的信号通路，为其进一步开发应用于原发性和转移性肿瘤的治疗提 供新的思路。 关键词：白藜芦醇；姜黄素；人参皂苷；自噬；癌症 Natural Compounds: Targeting Pathways of Autophagy as Anticancer Agents 1,2 1 1 3, * ZHANG Shu-fang , WANG Yu-fang , YUAN Hong , CHEN Ning (1. Graduate School, Wuhan Sports University, Wuhan 430079, China; 2. College of Sports Science and Technology, Wuhan Sports University, Wuhan 430205, China; 3. Hubei Provincial Collaborative Innovation Center for Exercise and Health Promotion, College of Health Science, Wuhan Sports University, Wuhan 430079, China) Abstract: Conventional chemotherapeutic agents are often toxic not only to tumor cells, but also to normal cells, limiting their therapeutic efficiency in clinical application. Novel natural anticancer compounds present an attractive alternative to synthetic compounds, based on their favorable safety and efficacy profiles. Pre-clinical and clinical studies have demonstrated that several representative natural compounds such as resveratrol, curcumin, and ginsenosides have anticancer potential. In this review, we summarize how natural compounds target autophagy to lead to cell death. We also discuss some involved core autophagic pathways. Recent advances in the discovery and evaluat