丙泊酚TCI个性化实施探讨课件.ppt

镇痛药物与丙泊酚TCI Future applications for TCI systems Among currently available analgesic drugs, alfentanil and remifentanil are considered to be the most suitable for administration by target controlled infusion Anaesthesia. 1998 Apr;53 Suppl 1:56-60. 短效镇痛药物瑞米芬太尼大剂量副作用明显 大剂量阿片类药物镇痛封顶效应 大剂量瑞米芬太尼麻醉苏醒后疼痛反跳 瑞芬太尼 Anaesthesist. 2010 Feb;59(2):126-34. 不同瑞芬浓度对丙泊酚 TCI靶浓度影响 RESULTS: Narcotrend, D(2)/E(0) 0.2, 0.4, or 0.6 microg/kg remifentanil propofol concentration was 3.02+/-0.86, 1.93+/-0.53 and 1.60+/-0.55 microg/ml respectively Women had a higher propofol consumption than men. 瑞芬太尼vs芬太尼 RESULTS: Patients in group R exhibited a faster recovery. The incidence of nausea and vomiting was similar in the 2 groups. There was a reduction in the amount of propofol used in group R Minerva Anestesiol. 2006 May;72(5):309-19 Propofol and sufentanil for gynecological laparoscopic surgery. RESULTS: Sufentanil (0.2 ng/ml) skin incision(EC(50) ) and (EC(95) ) were 2.2 and 3.7 microg/ml, respectively. The predicted propofol EC(50) and EC(95) to maintain adequate were 2.6 microg/ml ( 2.3-2.7 microg/ml) and 3.6 microg/ml (3.3-4.0 microg/ml), respectively Acta Anaesthesiol Scand. 2011 Jan;55(1):110-7 Ketamine effect on bispectral index during propofol-remifentanil anaesthesia. RESULTS: 0.2 mg kg(-1) ketamine administered over a 5 min period did not increase the BIS value over the next 15 min. 0.5 mg kg(-1) is associated with an increase in the bispectral index (BIS) values that can lead to an overdose of hypnotic agents Br J Anaesth. 2009 Mar;102(3):336-9 Dexmedetomidine on the adjuvant propofol requirement and intraoperative hemodynamics.. RESULTS: The propofol infusion rate was significantly lower in the DEX group than in group C (63.9 ± 16.2 vs. 96.4 ± 10.0 μg/kg/min, respectively; P 0.001). The changes in MAP% at T-induction, T-trachea and T-incision in group DEX (-10.0 ±3.9%, -9.4 ± 4.6% and -11.2 ± 6.3%, respectively) were significantly less than those in group C (-2