维生素A的介绍中.ppt

第五章维 生 素 A;Vitamin A – History ? Ancient Egypt --- cure night blindness by topical application of liver to eye ? Ancient Greeks --- cure by eating liver ?孙思邈(581-682年) 首先用猪肝治疗“雀目”(夜盲症) ? 1913 --- 2 groups purified fat soluble factor needed for growth of rats - McCollum and Davis found it was in butter or egg yolk, not lard - Osborn and Mendel, found in cod liver oil and butter ? 1930 --- structure identified; conversion of ?-carotene to Vit. A;一、维生素A的性质、吸收与代谢;维生素A衍生物的分子式;Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd.; ;Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd.;;β-胡萝卜素结构式;Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd.;β-胡萝卜素水解为维生素A;Structure of Vitamin A and ?--Carotene ;Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd.;类胡萝卜素化合物的生物活性（以β-胡萝卜生物活性为100%） ;二、维生素A及胡萝卜素的代谢 1.维生素A的吸收;Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd.;Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd.;Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd.;Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd.;? Intestinal Absorption - Dietary retinyl esters must be hydrolyzed pancreatic carboxyl(Cholesterol ester) hydrolase retinyl ester hydrolase - beta carotene carotene 15,15’ dioxygenase ? Passive diffusion of retinol into enterocyte ? Re-esterification in enterocyte(palmitate and stearate) - LRAT(lecithin retinol acyl transterase) - ARAT(acyl-coA:retinol acyltransferase ? Packaging