去氢枞酸衍生物生物活性研究新进展-林产化学与工业.PDFVIP

蕝蕝蕝蕝蕝蕝蕝蕝藚 藚 蕝 蕝 综 述 评 论 蕝 蕝 藚 藚蕝蕝蕝蕝蕝蕝蕝蕝 去氢枞酸衍生物生物活性研究新进展 1 1 1* 2 崔艳杰 ,饶小平 ,商士斌 ,宋 杰 (1. 中国林业科学研究院林产化学工业研究所;生物质化学利用国家工程实验室;国家林业局林产 化学工程重点开放性实验室;江苏省生物质能源与材料重点实验室, 江苏 南京 210042; 2.密西根大学-弗林特化学与生物化学系, 美国 弗林特 48502) 摘摇 要:摇 去氢枞酸是一种重要的松香衍生物,化学结构中含有苯环及多个手性中心,其衍生物表 CUI Yan鄄jie摇 摇 现出广泛的生物活性,在医药及农药等领域有着重要的用途。 根据去氢枞酸的结构特点,通过对羧 基进行典型的羧基反应,如酯化、成酰氯、还原成胺、还原成醇及脱羧降解等,以及对芳环进行亲电取代、去异丙基等,合 成了一系列具有生物活性的衍生物。 主要从羧基改性衍生物生物活性、芳环改性衍生物生物活性两个方面,综述了近几 年来去氢枞酸衍生物生物活性研究新进展。 关键词:摇 去氢枞酸;衍生物;生物活性 中图分类号:TQ351.47摇 摇 摇 摇 摇 摇 文献标识码:A摇 摇 摇 摇 摇 摇 文章编号:0253-2417(2012)06-0099-08 Recent Advances on Biologic Activity of Dehydroabietic Acid Derivatives 1 1 1 2 CUI Yan鄄jie ,RAO Xiao鄄ping ,SHANG Shi鄄bin ,SONGJie (1.Institute of Chemical Industry of Forest Products,CAF;National Engineering Lab.for Biomass Chemical Utilization; Key and Open Lab.of Forest Chemical Engineering,SFA;Key Lab.of Biomass Energy and Material, Jiangsu Province,Nanjing210042,China;2.Department of Chemistry and Biochemistry, University of Michigan鄄Flint,Flint MI48502,USA) Abstract:Dehydroabietic acid is an important derivative of rosin. It has benzene ring and several chiral centers,and its deriva鄄 tives exhibit wide range of bioactivities. They have important application in the pharmaceutical and insecticidefields. According to the structural characteristics, a series of bioactive derivatives of dehydroabietic acid were synthesized by typical carboxyl reaction,including esterification,synthesizing acyl chloride,being amine or alcohol by reduction,decarboxylated degradation, and electrophilic substitutions,r