心血管系统发育.pptVIP

The inhibitors and activators serum response factor, SRF Wnt FGF 参考书： Ang-1/Tie-2 and the wall of blood vessel Tie-2 is a receptor tyrosine kinase expressing in vascular endothelium. Except for the vasculogenesis and angiogenesis, Tie-2 is necessary for vascular remodeling. Tie-2 is the receptor of Ang -1 and Ang -2. The Ang-1s function is to promote the formation of the vascular wall, to ensure the integrity and stability of new vessels. Ang-2 only exists in the trimming process. p232 Perivascular mesenchymal cells produce Ang-1, which is surrounded by Tie-2 located on the surface of endothelial cells. Under the interaction of Ang-1 and Tie-2, signal molecule in endothelial cells was stimulated and released, such as platelet-derived growth factor (PDGF). The release of PDGF induced mesenchymal cells migrating to vascular endothelium. When endothelial cells and mesenchymal cells contact, endothelial cells release transforming growth factor beta (TGF-β) to transform the mesenchymal cells into vascular smooth muscle cells or pericytes (a cell close to the capillary wall outside). p232 figure (4) FGF FGFR(5) PDGF-beta PDGFRIn addition, ECM and cell adhesion molecule are also play important role in angiogenesis. The components of ECM, such as fibronectin, collegen, intergrin and vascular endothelial cadherin, all take part in the proliferation and migration of endothelial cells. p233 VEGF blockade differentiation of endothelial cells into vein through activation of Notch signaling pathway the molecular markers of vein is suppressed, meanwhile the expression of artery molecular markers is activated, when the Notch signal is activated ephrinB2 express in arterial endothelial cells and its receptor EphB4 express in the venous endothelial cells 6. The separation of artery and vein 7. Fetal blood circulation p237 Part two. Development of heart 1. Development of heart 2. Mechanism of the heart development 3. Heart defect p216 17d 27-37d 22d 1. Development of heart (