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Sun-苦参黄酮实验
PHYTOTHERAPY RESEARCH
Phytother. Res. 21, 269–277 (2007)
Published online 21 December 2006 in Wiley InterScience
ANTITUMOR ACTIVITIES OF KUSHEN FLAVONOIDS 269
() DOI: 10.1002/ptr.2066
Novel Antitumor Activities of Kushen
Flavonoids In Vitro and In Vivo
1,2 1,2 1 1 1 1
Mingyu Sun , Jun Han , Jifeng Duan , Yumin Cui , Tao Wang , Weihan Zhang ,
Wei Liu1 1 2 2 1
, Jianrong Hong , Minghui Yao , Sidong Xiong and Xiaoqiang Yan
1Departments of Biology and Pharmacology, Hutchison Medipharma Ltd., Zhang Jiang Hi-Tech Park, Shanghai 201203, China
2Department of Immunology and Pharmacology, Shanghai Medical College, Fudan University, Shanghai 200032, China
Kushen (KS), the dried roots of Sophora flavescens Aiton, has a long history of use in traditional Chinese
medicine to treat inflammatory diseases and cancer. Kushen alkaloids (KS-As) and Kushen flavonoids (KS-Fs)
are the well characterized components in KS. KS-As have been considered biologically active and developed
in China as anticancer drugs. In an effort to screen novel antitumor agents from botanicals, more potent
antitumor activities were identified in KS-Fs than in KS-As. KS-Fs were able to inhibit the growth of a panel
of tumor cell lines and enhanced the antitumor activities of Taxol in vitro. The antitumor activities of KS-Fs
and Kur, a single KS-Fs compound, were demonstrated in murine and xeno
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