酒精性骨质疏松的试验研究.PDFVIP

中国骨质疏橙杂志 1998年4月第4卷第 朝 31 酒精性骨质疏松的实验研究 王义生 李月白 毛克亚 摘要 为了证明酒精中毒导致骨质疏松，本实验取健康新西兰种家兔80H． 随机分为实验组和对照组，每组40只。采用灌胃法，实验纽给予烈性酒(含乙醇 45 )10m[／(kg-d)．对照组给予10 的葡萄糖溶液 10ml(kg·d)。两组动物在 实验第1、2、3、5月时分批处死。观察股骨头的病理组织学改变。结果显示：与对照 组相比，实验组结果显示股骨头髓内脂肪细胞增多、增大．空骨略窝百分比升高， 骨小梁变细、稀疏，骨小粱面积分数降低。透射电镜下见股骨头软骨下骨细胞内 脂质沉积，甚或脂肪充满整个骨陷窝，骨细胞固缩、死亡 放射学检查显示，骨皮质 变薄，骨密度降低。这些结果提示，长期过量饮酒发生的酒精中毒可导致骨质疏松，后者是股骨头缺血性 坏死的 个发病因素。 关键词 家兔 酒精 骨质疏松 Preliminarystudyonalcoholinducedosteoporosis WangYisheng，LiYuebaiandMaoKeya DepartmentofOrthopaedics，TheFirstAffiliatedHospitalofHenanMedicalUniversity，Zhengzhou450052，China Abstract Theaim ofthisstudywastodeterminewhetheralcoholism canindueeosteoporosis．80 NewZealandwhiterabbitswererandomlydividedintotwogroups．40rabbitswereadiainisteredliquor containing45 alcohol10mlkg ·dbyperfusionintostomach．Theremaining40rabbitsweregiven 10 glucosesolution10ml／kg ·dbythesamemethod，servingascontrols．Theanimalsfrom thetvgo groupsweresacrificaedinbatches1，2，3tand6monthsafterthestartoltreatmentWeobservedthe h1st0path0l。g1calchangesinheadoffemor．TheresultsshowedthatinaLcoholtreatedanimals，themar ro~．rfatcellsinthefemoralheadincreasedandenlarged ThepercentageofemptyOSSEOUSlacunaein creased，Thetraheculaebecamethinandsparse，andtheirareafractiOnreduced．Onexaminationofsub— chondralosteocytesoftheheadbytransmisMonelectronmicroscope，lipiddepositionwasfoundinosteo— cytes．ortheOSSEOUSlacunaewerefilledwithfatentirely-andtheosteocyteswerepyknoticanddeadin thealcoholgroup．Radiologicalexaminationshowedthathonecortexbecamethinandthedensityre duced．Theseevidencessuggestthat[ong—term excessiveintakeofalacolicliquorcani