肝素结合表皮生长因子及其在恶性肿瘤中的作用-现代生物医学进展.pdfVIP

4566 · · 现代生物医学进展 Progress in Modern Biomedicine Vol.12 NO.23 AUG.2012 肝素结合表皮生长因子及其在恶性肿瘤中的作用 李翠萍 卢美松△ 150001 （哈尔滨医科大学附属第一医院妇产科黑龙江哈尔滨 ） 摘要：肝素结合表皮生长因子属表皮生长因子超家族成员之一，可促进多种细胞分裂和增殖，参与多个病理生理过程。近年研究 发现肝素结合表皮生长因子可参与肿瘤发生发展的各个环节，在肿瘤化疗耐药中也发挥一定作用，使其成为恶性肿瘤生物学治 疗的靶向因子。其与白喉毒素结合的特性为临床提供了一种新的治疗癌症的途径。继续对HB-EGF 进行深入的研究，并将已获得 的知识与临床治疗结合，将有望产生新的治疗恶性肿瘤的途径及新型的抗肿瘤药物。 CRM197 关键词：肝素结合表皮生长因子；肿瘤； R730.231 A 1673-6273 2012 23-4566-03 中图分类号： 文献标识码： 文章编号： （ ） HB-EGF and its Role in Cancer LI Cui-p ing, LU Mei-song△ (Dep artment of gynaecology and obstetrics The First Affiliated Hosp ital of Harbin Medical University,Harbin 15000 1,China) ， ABSTRACT: Heparin-binding epidermal growthfactor (HB-EGF), which belongs to the epidermal growthfactor (EGF) family,has been implicated as a contributer to a variety of physiological and pathological processes. Moreover, HB-EGF has been shown to stimulate the growth and proliferation of variety of cells .In recent years, HB-EGF has also been found to be implicated in each of the hallmarks characteristic of neoplastic disease and in the resistance to chemotherapy of tumor making it a targeted factor for biological therapy of cancer.Its unique identity as a receptor for diphtheria toxin may provide novel avenues for cancer therapeutics.The future challenge will be to lucubrate HB-EGF and to translate our knowledge of this inimitable molecule into treatments,then we can expected new ways and new drugs for cancer. Key words: Heparin-binding epidermal growthfactor; Cancer; CRM197 Chinese Library Classification(CLC): R730.231 Document c