淫羊藿中活性成分的代谢产物研究进展-天津中草药杂志社.pdfVIP

• 78 • 现代药物与临床 Drugs Clinic 第 28 卷 第 1 期 2013 年 1 月 淫羊藿中活性成分的代谢产物研究进展 1 2, 3 2, 3 2, 3 2, 3* 韩 惠 ，单 淇 ，周福军 ，张新鑫 ，侯文彬 1. 天津中医药大学，天津 300193 2. 天津药物研究院，天津 300193 3. 中药现代制剂与质量控制技术国家地方联合工程实验室（天津），天津 300193 摘 要：淫羊藿为我国传统中药，具有补肾阳、强筋骨、祛风湿的功效。淫羊藿中主要活性成分是以淫羊藿苷为代表的黄酮 苷类化合物。近年来研究发现淫羊藿给药后发挥功效的物质基础主要为其活性成分的代谢产物。综述近年来国内外对淫羊藿 中活性成分的代谢产物的研究方法及代谢产物研究进展，对进一步阐明淫羊藿药材的作用机制、研制新药具有直接指导意义。 关键词：淫羊藿；淫羊藿苷；朝藿定 A ；宝藿苷Ⅰ；代谢产物 中图分类号：R282.71 文献标志码：A 文章编号：1674 - 5515(2013)01 - 0078 - 05 DOI: 10.7501/j.issn.1674-5515.2013.01.022 Research progress in metabolites of active constitutes from Epimedii Herba 1 2, 3 2, 3 2, 3 2, 3 HAN Hui , SHAN Qi , ZHOU Fu-jun , ZHANG Xin-xin , HOU Wen-bin 1. Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China 2. Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China 3. State and Local Joint Engineering Laboratory of Preparation and Quality Control Techniques for TCM (Tianjin), Tianjin 300193, China Abstract: Epimedii Herba is one of the traditional Chinese materia medica with the function of invigorating kidney, strengthening yang , and eliminating wind and dampness. Flavonoid glycosides of icariin as the representative, are the main active chemical components in Epimedii Herba . Recent studies have found that the material basis of these compounds may be their metabolites in vivo. The paper reviews the research progress in the metabolites of the active constituents in Epimedii Herba, which could provide the effective guidance for further understanding their mechanism and the development of the related drugs. Key words: Epimedii Herba ; icariin; epimedin A; baohuoside Ⅰ; metabolites 淫 羊 藿 为 小 檗 科 植 物 淫 羊 藿 Epimedium 物吸收进入体内；大部分静脉给药的黄酮苷类化合