HBV_(RT) A181TV突变.pptVIP

* 体外对NAs敏感性下降10倍以内对于临床病毒学应答影响小 * EASL Adefovir resistance: it is recommended to switch to tenofovir if available and add a second drug without crossresistance. If an N236T substitution is present, add lamivudine, entecavir or telbivudine or switch to tenofovir plus emtricitabine (in one tablet) (C1). If an A181T/V substitution is present, add entecavir (the safety of the tenofovir–entecavir combination is unknown) or switch to tenofovir plus emtricitabine (B1). AASLD Adefovir-resistance Add lamivudine# Stop adefovir, switch to Truvada*∧ Switch to or add entecavir#∧ AGA Adefovir resistance ● C