一个人类新基因znf322的研究初报-湖南师范大学.pdfVIP

5 2 生命科学研究 Vol.5 No .2 2 0 0 1 6 Life Science Research June 2001 a ZNF322 李永青, 曾伟奇, 朱传炳, 皮花亮, 戴　琦, 吴秀山 ( , 4 10081) : 利用果蝇心脏发育基因zf h-1的 cDNA 序列和计算机克隆方法, 在 9 号染色 上发现了一个新的人 类同源基因. 经国际基因命名委员会批准, 命名为ZNF 22. 该基因总长度约为2. 8 kb, 为一个连续的序列, 编码 一个402 个氨基酸的蛋白质, 与小鼠 - 5 编码的蛋白质最相似( 同源度为51. 4%) . 该基因在人 肾、 zf p 脑、结肠、胚胎心脏及黑色素瘤等多种组织中广泛表达, 其功能有待深入研究. :ZN F 22 基因; 计算机克隆; 新基因 : 785: : 1007-7847( 2001) 02-014 1-05 Q A Primary Studies on a Novel Human ZNF322 Gene - , - , - , LI Yong qing ZENG Wei qi ZHU Chuan bing PI Hua-liang, DAI Qi, WU Xiu-shan ( Colleg e of L if e S ciences, H unan N ormal Univ ersity , Changsha 410081, H unan, China) Abstract: Based on the cDNA sequence of the zf h-1 gene in Drosop hila, a novel human homolog located on chromosome 9 was found by computer cloning method. The gene is named ZN F 22, w hich . 2. 8 is approved by HUGO Gene Nomeclature Committee Its mRNA is about kb and there is no intron in it T he gene encodes a protein of. 402 amino acids w hich is the best similar to the mouse, protein encoded by zf p - 5 ( 51. 4% ) . Its EST s appeared in many kinds normal tissues, such as kidney , brain, colon and fetal heart, and in melanoma or other tumor tissues. T he function of the gene remains to be studied. Key words: ZN F 22 gene ; computer cloning; novel gene (L fi e Science Research, 2001, 5( 2) : 14 1 ～145) DNA EST ( htt