抗体药物偶联体在癌症治疗中的应用.pptVIP

* * * * Catalogue： 1·抗体药物偶连体（ADCs）如何进攻癌细胞 2·TARGET SELECTION其中 Expression profiling（表达性能分析）是关键方面然后讲了Immunohistochemistry（免疫蛋白组化学）和 Flow cytometry（流细胞计数法）来做表达性能分析都有缺点，然后又讲了mRNA水平的表达性能分析被广泛应用于靶点评估 3.Tumor Expression of Antigen（肿瘤抗原的表达） Drugs and linkers commonly used in ADCs. Conventional chemotherapeutics such as doxorubicin（阿霉素） were once used for ADCs but have been superseded for this purpose by more potent drugs including calicheamicins（加利车霉素）, maytansinoids （美登霉素生物碱）(DM1 and DM4) and auristatins（奥瑞他汀） (MMAE and MMAF). Commonly used linkers in ADCs include hydrazones, disulfides, and pepti