固相萃取技术在药物分析中的应用-天津中草药杂志社.pdfVIP

现代药物与临床 Drugs Clinic 第 28 卷 第 2 期 2013 年 3 月 • 261 • 固相萃取技术在药物分析中的应用 1 2 3 1 2* 李 佩 ，李银峰 ，王杰晶 ，张园园 ，靳朝东 1. 天津中医药大学，天津 300193 2. 天津药物研究院 分析测试中心，天津 300193 3. 河南大学 药学院，河南 开封 475001 摘 要：固相萃取技术是一种在20 世纪 70 年代初发展起来的样品预处理分离富集技术，具有操作简单、省时，易实现自动 化等优点，广泛应用在制药、食品、环境、商检、化工等领域。固相萃取技术与高效液相色谱（HPLC ）或液相色谱（LC ）、 质谱（MS ）法等分离检测手段联用，从而实现样品在线预处理，使其在组合化学、高通量筛选等药学领域的应用日益增多。 简要介绍了固相萃取技术在化学药、中药及天然药物、生物药中的应用。 关键词：固相萃取；样品预处理；药物分析；化学药；天然药物 中图分类号：R917 文献标志码：A 文章编号：1674 - 5515(2013)02 - 0261 - 04 DOI :10.7501/j.issn.1674-5515.2013.02.040 Application of solid-phase extraction technology in pharmaceutical analysis 1 2 3 1 2 LI Pei , LI Yin-feng , WANG Jie-jing , ZHANG Yuan-yuan , JIN Chao-dong 1. Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China 2. Center for Instrumentation Analysis, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China 3. College of Pharmacy, Henan University, Kaifeng 475001, China Abstract: Solid phase extraction technology is a sample pretreatment and enrichment technology, developed in the early 1970s, with the advantages of simple procedure, short time, and easy automation, etc. It is widely used in the fields of pharmacy, food, environment, commercial inspection, chemical industry, and so on. Solid phase extraction technology, combined with the separation detection methods of high performance liquid chromatography (HPLC), liquid chromatography (LC), or mass spectrometry (MS), could accomplish the online sample pretreatment and increase its application in combinatorial chemistry and high flux screening of pharmacy. This review briefly introduces the application of solid phase extraction technology in pharmaceutical chemicals, traditional Chinese medic