果蔬源胰脂肪酶抑制剂的筛选-吉林农业大学学报.pdfVIP

吉林农业大学学报 2011，11 Journal of Jilin Agricultural University E-mail:jlndxb@ 果蔬源胰脂肪酶抑制剂的筛选* 1,2 3 4 1 4∗∗ 刘 蕊 ，张景照 , 郑毅男 ，徐宝军 ，刘文丛 1. 北京师范大学-香港浸会大学联合国际学院，珠海 519085；2. 香港浸会大学，香港 100085；3.贵阳 医学院药学院，贵阳 550004；4.吉林农业大学中药材学院，长春 130118 摘 要：通过从三油酸甘油酯释放油酸的释放率来判定胰脂肪酶活性的方法，研究并比较了 30 种果蔬乙醇提取物的 减肥作用。30 种果蔬 70% 乙醇提取物对胰脂肪酶作用的测定结果表明：青辣椒乙醇提取物对胰脂肪酶的抑制作用最 强，抑制率为 46.15% ，山竹提取物抑制率为29.87% ，白萝卜、柠檬和圣女果提取物对胰脂肪酶的抑制率均达到20% 以上。大蒜提取物对胰脂肪酶有较强的促进作用（29.64% ），陈皮和山楂提取物对胰脂肪酶的促进率分别为6.38%和 7.66% 。 关键词：果蔬；胰脂肪酶；减肥；甘油三酯；油酸 中图分类号：Q946.5 文献标识码：A 文章编号：1000-5684(2011) CNKI:22-1100/S1533.004 DOI: /kcms/detail/22.1100.S1533.004.html 网络出版地址： Screening Pancreatic Lipase Inhibitors from Fruits s and Vegetables 1,2 3 4 1 4, LIU Rui , ZHANG Jing-zhao , ZHENG Yi-nan , XU Bao-jun , LIU Wen-cong 1. BNU-HKBU United International College, Zhuhai 519085, China；2. Hong Kong Baptist University, Hong Kong 100085, China ；3. School of Pharmacy, Guiyang Medical University, Guiyang 550004, China ；4. College of Chinese Medicinal Materials, Jilin Agricultural University，Changchun 130118，China Abstract: The objective was to evaluate the anti-obesity effects of ethanol extracts of 30 kinds of fruits and vegetables. The authors investigated their inhibitory activity against pancreatic lipase by determining the release of oleic acid from triolein. The results showed that ethanol extract of green pepper exhibited the strongest pancreatic lipase inhibitory activity and the inhibition rate was 46.15%. The anti-lipase activity of mangosteen extract was in the second. In addition, the pancreatic lipase inhibition rate of white radish, lemon and small tomato extra