磷脂酶d与肿瘤的关系.pdfVIP

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磷脂酶d与肿瘤的关系

2006 3 29 2  International Journal of Immunology, March 2006, Vol 29.No.2 ·89 · 19 Basketter DA, Andersen KE, Liden C, et al.Evaluation of the skin sensi- against contact hypersensitivity.J Immunol, 2003, 171(3):1164-1171. tizing potency of chemicals by using the e isting methods and consider- 22 Mimura T, Shinozaki Y, Kawasaki H, et al.JTP-27536 [ (+)-1, 3-di- ations of relevance for elicitation.Contact Dermatitis, 2005, 52(1):39- hydro y-2-hydro ymethylpropyl-2- ammonium 2-[ (R)-3-cyclo-he yl-1- 43. phenylpropyl]-1, 3-dio o-2, 3-dihydro-1H-isoindole-5-carbo ylate mono- 20 Ruckert R, Brandt K, Hofmann U, et al.IL-2-IgG2b fusion protein sup- hydrate], a novel inhibitor of immunoglobulins and interleukin-5 with an- presses murine contact hypersensitivity in vivo.J Invest Dermatol, 2002, ti-inflammatory properties in mouse allergic dermatitis model.J Pharma- 119(2):370-376. col E p Ther, 2005, 314(1):293-301. 21 Plitz T, Saint-Mezard P, Satho M, et al.IL-18 binding protein protects (:2005-03-31) D 王亚雄  D(PLD), (PC)。 , PLD (PA)(DAG), PLD 。 , PLD , PLD 。  D;;;;  1673-4394(2006)02-0089-04    R730.2     A Phospholipase D and Tumor WANG Ya-iong (Department of Immunology , Fuj ian Medical University ,F uzhou 350004, China ) Abstract  Phospholipase D (PLD)is an important signaling molecule,which can hydrolyse phos- phatidylcholine (PC)into phosphatidic acid (PA )and choline.Furthermore, PA and its hydrolys- is product, diacylglycerol (DAG), are important lipid second messengers.Hence, the activition of PLD involves in multiple signling pathways.A large body of evidence indicates that the activity of PLD is significantly increased in a variety of tumours and PLD is tightly involved in biological be- haviors of tumor cells. Key words Phospholipase D;Tumorigenesis;Differentiation;Apoptosis;Tumor metastasis   D (phospholipase D, PLD) PLD1 1 074 、1

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