植物关联分析方法的研究进展.pdfVIP

作物学报 ACTA AGRONOMICA SINICA 2016, 42(7): 945956 / ISSN 0496-3490; CODEN TSHPA9 E-mail: xbzw@ DOI: 10.3724/SP.J.1006.2016.00945 植物关联分析方法的研究进展 冯建英1 温阳俊1 张 瑾1 章元明2,* 1 , 210095; 2 , 430070 : , , , ; , ; , , , , : ; ; ; Advances on Methodologies for Genome-wide Association Studies in Plants 1 1 1 2,* FENG Jian-Ying , WEN Yang-Jun , ZHANG Jin , and ZHANG Yuan-Ming 1 State Key Laboratory of Crop Genetics and Germplasm Enhancement, Nanjing Agricultural University, Nanjing 210095, China; 2 College of Plant Science and Technology, Huazhong Agricultural University, Wuhan 430070, China Abstract: Genome-wide association studies (GWAS) have been widely used in human, animal and plant genetics, and many new approaches and their softwares have been developed in recent years. To make a better use of the GWAS methods in applied research, in this study we summarized the advances on methodologies and softwares for GWAS. First, LD score regression was introduced to investigate the effect of population structure on GWAS. Then, the main approaches and their softwares for GWAS in plants were reviewed, including a single-locus model, a multi-locus model, epistasis, and multiple correlated traits. Finally, we prospected the future developments in GWAS. It should be noted that, in real data analysis at present, the met