柴胡白芍药对对慢性温和不可预知性应激抑郁模型-天津中草药杂志社.pdfVIP

中草药 Chinese Traditional and Herbal Drugs 第47 卷 第12 期 2016 年6 月 ·2137 · 柴胡白芍药对对慢性温和不可预知性应激抑郁模型大鼠行为学的影响 * * 路腾飞，于泽胜，姚 璐，高树明，周好波，李 琳，高 杉 ，于春泉 天津中医药大学，天津 300193 摘 要：目的 观察柴胡白芍药对对慢性温和不可预知性应激（CUMS ）抑郁模型大鼠行为学的影响，验证柴胡白芍药对的 抗抑郁作用。方法 基于 CUMS 抑郁大鼠模型观察给予柴胡白芍药对后大鼠的行为学改变，包括大鼠的体质量、糖水消耗 情况以及旷场实验活动行为情况。结果 给大鼠柴胡白芍药对 14 d 后，柴胡白芍药对低、中、高各剂量组大鼠的体质量、 糖水消耗量以及旷场实验中穿越横格数及直立次数均显著增加。说明柴胡白芍药对可以改善大鼠的抑郁行为。单用柴胡和单 用白芍也可以不同程度改善部分指标。结论 柴胡白芍药对对大鼠有明显抗抑郁作用。 关键词：柴胡白芍药对；柴胡；白芍；抗抑郁；慢性温和不可预知性应激抑郁模型；糖水消耗；旷场实验 中图分类号：R285.5 文献标志码：A 文章编号：0253 - 2670(2016)12 - 2137 - 05 DOI: 10.7501/j.issn.0253-2670.2016.12.020 Behaviour on effect of herb pair of Bupleuri Radix and Paeoniae Alba Radix in chronic unpredictable mild stress depression model of rats LU Teng-fei, YU Ze-sheng, YAO Lu, GAO Shu-ming, ZHOU Hao-bo, LI Lin, GAO Shan, YU Chun-quan Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China Abstract: Objective To validate the antidepressant effect of herb pair of Bupleuri Radix and Paeoniae Alba Radix by observing its interference effect in the chronic unpredictable mild stress (CUMS) depression model of rats. Methods After the interference of herb pair of Bupleuri Radix and Paeoniae A lba Radix in CUMS depression model of rats, those changes of rat body weight, sugar water consumption, and the opening activity behavior were observed. Results After the interference of herb pair of Bupleuri Radix and Paeoniae A lba Radix in CUMS depression model of rats for two weeks, the test indexes of rat body weight, sugar water consumption, and the opening activity behavior were significantly increased in low-, mid-, and high-dose herb pair of Bupleuri Radix and Paeoniae A lba Radix groups. The effect of herb pair of Bupleuri Radix and Paeoniae Alba Radix on improving the behavior