维生素D与辅助生殖：系统评价及meta分析.doc

维生素D与辅助生殖：系统评价及meta分析 吕诗诗，徐勇*，王吉英 （四川省泸州医学院附属医院内分泌科） 作者简介：吕诗诗，女，（1988-），硕士研究生，邮箱：906367269@，电话 *：通讯作者：徐勇，教授，邮箱：xywyll@ 摘要：目的：明确不孕女性体内维生素D水平与辅助生殖结局的关系。方法：我们在Embase、Cochrane和Pubmed数据库中进行检索，所有数据库均检索至2014年10月6号。文献由两名研究员独立进行质量评价，对存在异议的研究由双方商议决定是否纳入。研究结果的数据采用Stata 12.0软件进行分析。结果：总共检索文献131篇，10篇符合我们的纳入标准，最终有5篇文献纳入meta分析。人体内卵泡中维生素D与血清中维生素D水平存在正性线性关系。不孕女性体内维生素D＜20ng/ml时，可降低辅助生殖临床受孕率（RR=0.80，95%CI=0.67-0.96; P=0.32 ）及胎儿活产率( RR=0.76, 95%CI=0.61-0.93；P=0.54)。卵泡中的维生素D水平与血清中维生素D水平呈正性线性关系，合并r值(r=0.54；95%CI=0.45-0.63；P=0.432）。结论：女性体内卵泡中的维生素D水平可反映体内血清中维生素D的水平，不孕女性体内维生素D不足降低辅助生殖成功率。 [关键词] 维生素D；不孕；辅助生殖; meta分析 Vitamin D and In Vitro Fertilization: a systematic review and meta-analysis Lv ShiShi a, Wang JiYing a, Xu Yong a* a Department of Endocrinology, Affiliated Hospital of Luzhou Medical College, Luzhou, Sichuan 646000,China * Corresponding author. Fax: +86 0830 3165362. E-mail: xywyll@ (Y. Xu). Abstract objective: To assess the relationship between vitamin D and in vitro fertilization (IVF) in infertile woman. Methods: We searched Embase, Pubmed, and the Cochrane Central Register for Controlled Trials database through October 6, 2014. All articles were reviewed by two independent researchers and, if a discrepancy was noted, we discussed. Results data were summarized by Stata 12.0 software. Results: Our search resulted in the retrieval and screening of 131 studies. Of those, 10 studies met the eligibility criteria and included 5 studies in our meta-analysis finally. A significant linear correlation was found between the levels of 25OH-D in serum and follicular fluid. Vtamin D＜20ng/ml was associated with lower rates of clinic pregnancy（RR=0.80，95%CI=0.67-0.96; P=0.32 ）and live birth rate ( RR=0.76, 95%CI=0.61-0.93；P=0.54) than vitamin D＞20ng/ml in infertile woman with in vitro fertilization. Serum and follicular fluid 25(OH)D have a positive linear asso