细胞增生与凋亡的分子机制.pptVIP

Other molecules of Apoptosis Omi: most recently discovered proapoptotic protein released from mitochondria and shows much similarity to Smac. Cell death process three phases Induction or initiation phase （起始） Effector or decision phase（效应） activating hydrolase (protease and nuclease) Degradation phase（降解） digestion of protein, fragmentation of DNA Two main apoptotic pathways The activation of death receptors （死亡受体途径） Mitochondria pathway （线粒体途径） common pathway: activation of caspase cascade Major Apoptotic Pathways in Mammalian Cells Hengartner, M.O. 2000. N