Drugs For Right Left Sided Heart Failure：为左与右心衰竭的药物.ppt

Drugs For Right Left Sided Heart Failure Cardiac Glycosides Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors) Diuretics Cardiac Glycosides Digitoxin (Crystodigin) Digoxin (Lanoxin) Cardiac Glycosides : Mechanism Of Action Inhibits Na+-K+ ATPase And Impairs The Active Transport Of Sodium Potassium - Intracellular Sodium Concentrations Rise High Intracellular Na+ Deranges The Na+-Ca2+ Pump Which Allows Intracellular Ca2+ Concentrations To Rise Calcium Channels May Open Up And Allow Extracellular Calcium To Flow Into The Cell The Heart Will Beat More Forcibly And With Greater Velocity Glycosides Enhance Vagal Tone Over The Heart Slows The Heart Rate Slows The AV Node Conduction Velocity Increases The AV Nodal Refractory Period Glycosides Net Effect On The Heart Heart Rate Is Slowed Cardiac Contraction Is Greater Ejection Fraction Is Improved Increased Ejection Velocity The Heart Is A Better Pump Adverse Side Effects Of The Cardiac Glycosides Fatigue Delirium Anorexia Headaches Hallucinations Visual Disturbances Atrioventricular Blocks EKG Changes Associated With The Cardiac Glycosides Prolonged P-R Interval Inversion Of T-Wave S-T Segment Depression Glycosides - Medical Uses Atrial Flutter Atrial Fibrillation Paroxysmal Tachycardia Congestive Heart Failure Angiotensin Converting Enzyme Inhibitors Captopril (Capoten) Enalapril Maleate (Vasotec) Lisinopril (Prinivil, Zestril) Benazepril (Lotensin) Fosinopril (Monopril) Moexipril (Univasc) Quinapril (Accupril) Ramipril (Altace) Trandolapril (Mavik) CHF - How Does It Occur ? The Heart As A Pump Is Weakened Myocardial Infarction Ischemic Heart Disease Valve Dysfunction Disease Hypertension -- To Hypertrophy Idiopathic Cardiomyopathy The Failing Heart Causes : Low Blood Flow Systemically Aldosterone Is Released Renin Is Released Increased Sodium And Water Retention Increased Cardiac Workload Decreased Cardiac Pump Performance ACE InhibitorsMechanism Of Action Blocks Converting Enzyme From Changing A