聚乙二醇接枝聚乳酸的自组装纳米微球的制备及性能Preparationand.PDFVIP

聚乙二醇接枝聚乳酸的自组装纳米微球的制备及性能Preparationand.PDF

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聚乙二醇接枝聚乳酸的自组装纳米微球的制备及性能Preparationand

2008 66 Vol. 66, 2008 4 , 487491 ACTA CHIMICA SINICA No. 4, 487491 · · * ( 400044) (PEG)(PLA), . (2.164.32) 102 mg•mL 1; 1.12 103 mg•mL1; ; Zeta , , /pH ; , , pH , , . , , Zeta , , Zeta , . ; ; ; ; Preparation and Properties of Nanoparticles Self-assembled by Polyethylene Glycol-graft-poly(lactic acid) WANG, Bin PAN, Jun* LIU, Ying MI, Li ZHANG, Ting-Xiu (Research Center of Bioinspired Material Science and Engineering, Bioengineering College, Chongqing University, Chongqing 400044) Abstract Amphiphilic polymers have vivid odds in the nano-drug system for its special self-assembly character. Here the self-assembly properties of polyethylene glycol (PEG)-graft-poly(lactic acid) (PLA) (PEG-g-PLA, PPLA) were investigated to explore its potential application to drug delivery. The dissolubility 2 1 of PPLA in water was (2.164.32) 10 mg•mL according to eye judgment. The critical micelle con- 2 1 centration was 2.16 10 mg•mL obtained from a fluorospectrophotometer. The self-assembled aggre- gates of PPLA in water were nanoscale spheres observed by a transmission electron microscope. The parti- cle size and zeta potential tests by dynamic light scattering revealed that during preparation, the ratio of hy- drophilicity/hydrophobicity, the aqueous medium and the pH had great influences; while

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