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聚乙二醇接枝聚乳酸的自组装纳米微球的制备及性能Preparationand
2008 66 Vol. 66, 2008
4 , 487491 ACTA CHIMICA SINICA No. 4, 487491
· ·
*
( 400044)
(PEG)(PLA),
. (2.164.32) 102 mg•mL 1; 1.12 103
mg•mL1; ;
Zeta , , /pH ;
, , pH , , . ,
, Zeta ,
, Zeta , .
; ; ; ;
Preparation and Properties of Nanoparticles Self-assembled by
Polyethylene Glycol-graft-poly(lactic acid)
WANG, Bin PAN, Jun* LIU, Ying MI, Li ZHANG, Ting-Xiu
(Research Center of Bioinspired Material Science and Engineering, Bioengineering College,
Chongqing University, Chongqing 400044)
Abstract Amphiphilic polymers have vivid odds in the nano-drug system for its special self-assembly
character. Here the self-assembly properties of polyethylene glycol (PEG)-graft-poly(lactic acid) (PLA)
(PEG-g-PLA, PPLA) were investigated to explore its potential application to drug delivery. The dissolubility
2 1
of PPLA in water was (2.164.32) 10 mg•mL according to eye judgment. The critical micelle con-
2 1
centration was 2.16 10 mg•mL obtained from a fluorospectrophotometer. The self-assembled aggre-
gates of PPLA in water were nanoscale spheres observed by a transmission electron microscope. The parti-
cle size and zeta potential tests by dynamic light scattering revealed that during preparation, the ratio of hy-
drophilicity/hydrophobicity, the aqueous medium and the pH had great influences; while
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