中老年人2型糖尿病患者便秘与早期动脉粥样硬化相关性研究刘宇.docVIP

中老年人2型糖尿病患者便秘与早期动脉粥样硬化相关性研究 刘宇 张瑞凤201112 上海交通大学医学院附属仁济医院内分泌科200237上海市闵行区梅陇镇社区卫生服务中心（张卫、张瑞凤目的≥28kg/m２）人群中，采用多元Logistic回归方法研究便秘和早期动脉粥样硬化相关性。结果65.8±7.9岁，便秘患病率14.5%。在肥胖的2型糖尿病患者中，校正所有可能混杂因素后，与非便秘组相比，便秘组早期动脉粥样硬化患病风险增加118%（OR=2.13,95% CI=1.10-4.32）。结论 【关键词】2型糖尿病；便秘；早期动脉粥样硬化 The association study of chronic constipation and subclinical atherosclerosis in type 2 diabetes LIU Yu1，ZHANG Ruifeng2，LI Ruyi2，ZHANG Wei2 1Department of Endocrinology, South Campus, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 201112, China 2 Min hang Meilong Community Health Service Center，Shanghai 200237，China Correspondence author：ZHANG Wei，E-mail189.cn 【Abstract】Objective The aim of this cross-sectional study is to investigate the association of chronic constipation and subclinical atherosclerosis in middle-aged, and elderly type 2 diabetics. Methods Total of 1950 subjects aged 40 years and above in Shanghai Meilong community were recruited to undergo questionnaire interview, anthropometric measurements，and carotid ultrasound from March 2013 to September 2013.Chronic constipation was defined according to Rome Ⅲ?diagnostic?criteria. Subclinical atherosclerosis was defined as the presence of elevated carotid intimal-medial thickness or carotid plaques. The association of chronic constipation and subclinical atherosclerosis was investigated in non-obese and obese type 2 diabetics，respectively. Results The presence of chronic constipation is 14.5% in involved subjects with the mean age of 65.8±7.9 years. In obese type 2 diabetics, the risk of subclinical atherosclerosis in subjects with chronic constipation was increased 118% compared with those without（fully adjusted OR=2.13,95% CI=1.10-4.32）. Conclusions Chronic constipation was associated with increased risk of subclinical atherosclerosis in obese type 2 diabetics. 【Key words】Type 2 diabetes；Chronic constipation；Subclinical atherosclerosis 心血管疾病是我国中老年人群的主要死亡原因，探索其危险因素对心血管疾病的早期发现