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Drugs of Anti-Parkinson’s disease Department of Pharmacology Zhang Yan-mei Pathogenesis of Parkinson’s disease Parkinson’s disease (PD) is a progressive disorder of movement that occurs mainly in the elderly. The chief symptoms are: Tremor at rest, usually starting in the hands (‘pill- rolling’ tremor), which tend to diminish during voluntary activity Pathogenesis of Parkinson’s disease Muscle rigidity, detectable as an increased resistance in passive limb movement --Bradykinesia Suppression of voluntary movements (hypokinesis), due partly to an inherent inertia of the motor system, which m