HER2阳性乳腺癌中CD44v6的表达与曲妥珠单抗耐药的关系.pdfVIP

310 · · 现代生物医学进展 Progress in Modern Biomedicine Vol.11 NO.2 JAN.2011 HER2 阳性乳腺癌 中 CD44v6 的表达与曲妥珠单抗耐药的关系 王延桂 高美华△ （青岛大学医学院免疫教研室 山东 青岛 266021） 摘要 目的：探讨 曲妥珠单抗在治疗 HER2 阳性 的转移性乳腺癌时 ，产生耐药性与 CD44v6 表达的相关性 。方法 ：共 66 例 HER2 阳 性转移性乳腺癌患者入组 。接受 曲妥珠单抗治疗的患者 37 例 ，其中 18 例获得了治疗前和治疗后转移性癌组织 。采用免疫组化 S - P CD44v6 CD44v6 法对治疗前 、治疗后 的不同乳腺组织进行 表达的研究。结果 ： 在经 曲妥珠单抗治疗产生耐药的活检组织 中阳 CD44v6 性表达程度明显高于治疗前 。结论 ： 的表达与曲妥珠单抗耐药相关 。 CD44v6 HER2 关键词 ：乳腺癌 ； ； ；曲妥珠单抗 ；转移性乳腺癌 R737.9 A 1673-6273 2011 02-310-04 中图分类号 ： 文献标识码 ： 文章编号 ： （ ） Relationship between Expression of CD44v6 and Resistance of Trastuzumab Chemotheraphy in Metastatic Breast Cancer Patients with HER2 Positive WANG Yan -gui, GAO Mei-hua△ (Dep artment of Immunology, Qingdao University Medical College, Qingdao, 26602 1, China) ABSTRACT Obj ective: To explore the correlation between the expression of CD44v6 and resistance of trastuzumab chemotheraphy for metastatic breast cancer patient with HER2 positive. Methods: 66 metastatic breast cancer patients with HER2 positive were eligible. Among 66 patients, 37 were received trastuzumab and there were 18 patients who had tumor tissues before and after therapy. All species ， were analyzed by S-P immunohistochemical method using the monoclonal antibody CD44 v6. Results: CD44v6 in breast cancer tissues of resistance to traszuzumab were signifcantly higher than before the treatment. Conclusion : There may be correlation between the expression of CD44v6 and resista