蛋白质氨基酸网络进展.pdfVIP

190 · · 现代生物医学进展 Progress in Modern Biomedicine Vol.11 NO.1 JAN.2011 蛋白质氨基酸网络研究进展* 1△ 2 1 1 常 珊 焦 雄 王美华 田绪红 1 510642 2 030024 （华南农业大学信息学院 广东广州 ；太原理工大学应用力学与生物医学工程研究所山西太原 ） - 摘要：氨基酸网络是运用复杂网络工具对蛋白质结构 功能关系研究的新方法。本文回顾了氨基酸网络中常用网络参量的计算方 法，如：度分布，聚集系数，平均最短路径等。结合本研究小组的工作，介绍了常用的网络构建和分析方法，并总结了氨基酸网络在 蛋白质折叠以及蛋白质分子对接问题中的应用。最后，分析了氨基酸网络研究目前存在的主要问题，并对未来的工作进行了展 望。 关键词：蛋白质；复杂网络；氨基酸网络 Q591 Q615 A 1673-6273 2011 01-190-04 中图分类号： ， 文献标识码： 文章编号： （ ） Progress in Amino Acid Networks of Proteins * 1△ 2 1 1 CHANG Shan , JIAO Xiong , WANG Mei-hua , TIAN Xu -hong ( 1 College of Informatics, South China Agricultural University, Guangzhou, Guangdong 510642, China ; 2 Institute of App lied Mechanics and Biomedical Engineering, Taiyuan University of technology, Taiyuan, Shanxi 030024, China) ABSTRACT: Amino acid network is a new approach on the relationship between protein structure and function by using the tech- nology of complex network. In this article, we reviewed the computational methods of mainly network parameters in amino acid network, such as the degree distribution, the clustering coefficient and the average minimal distance. Combining the research groups works, we introduced the commonly used constructing and analyzing methods of amino acid network. Meanwhile, we concluded the application on protein folding and protein docking. Finally, the existing major questions of amino acid network were analyzed and the prospects of the future study were made. Key