华蟾素治疗胃癌疗效的系统评价.pdfVIP

2012 27 West China Medical Journal Vol.27 No.9 Sep. 2012 1329 1 2 Cochrane2011 3 PubMed1966 1 2011 9 EMBASE 1974 1 2011 9 CBM1978 1 2011 9 1989 1 2011 9 1994 1 2011 9 RCTRCT RevMan 5.0 Meta 9 RCTMeta [RR=1.2395%CI 1.031.46P=0.02]1 [RR=1.2895%CI 0.692.36P=0.43] A Efficacy of Cinobufacin for Stomach Cancer: A Systematic ReviewSHUAI Yun-fang1 2 , YOU Li-hua . 1. The People’s Hospital of Qingshen County, Meishan, Sichuan 620460, P. R. China; 2. Department of Pharmacy, People’s Hospital of Chongzhou City, Chongzhou, Sichuan 611230, P. R. China Abstract Objective To assess the effi cacy of cinobufacin in the treatment of stomach cancer. Methods The Cochrane Library (the 3rd volume, 2011), PubMed (January 1966 – September 2011), EMBASE (January 1974 September 2011), CBM (January 1978 September 2011), VIP (January 1989 September 2011) and CNKI (January 1994 September 2011) databases were searched. Some related journals were also manually searched. Randomized controlled trails (RCTs) associated with cinobufacin for stomach cancer were included, as well as evaluated and analyzed by the software RevMan 5.0. Results Nine studies were included. The results of meta analysis demonstrated that cinobufacin combined with routine chemotherapy was superior to routine treatment in total effective rate [RR=1.23, 95%CI (1.03, 1.46), P=0.02] and survival rate one year after the treatment [RR=1.28, 95%CI (0.69, 2.36), P=0.43]. Conclusions Cinobufacin is effective for stomach cancer . However, due to limited quantity and quality of the included studies, we can