外文文献汇报- Regulatory T cells attenuateu000bexperimental periodontitisu000bprogression in mice.pptVIP

Regulatory T cells attenuateexperimental periodontitisprogression in mice Thank you! * J Clin Periodontol 3.549 缩略词： Tregs : regulatory T cells anti-GITR: anti-glucocorticoid-inducible tumour necrosis factor receptor CTLA-4 : cytotoxic T lymphocyte-associated molecule 4 TGF- β : transforming growth factor- β periodontopathogens immune reactions microbial factor persistent release of inflammatory mediators results in the destruction of periodontal tissues . TNF-a 、IL-1b Th1- and Th17-type cytokines The regulatory mechanisms involved in the control of PD severity remain relatively Anti-inflammatory cytokines and immunoregulatory factors are expressed in diseased periodontal tissues and are thought to be associated with lower disease severity. unknown IL-10, TGF- β , CTLA-4 the theoretical role played by Tregs in the control of periodontal infection and in the determination of disease outcome remains to be determined. A previous study demonstrated an increased frequency of Tregs in healthy tissues , suggesting a role for Tregs in the maintenance of periodontal health. subsequent reports : an increased frequency of this Treg in disease tissues, could also be indicative of a destructive role for Tregs in periodontitis . Conflict regulatory T cells(Tregs) is potentially involved in PD pathogenesis suppose Tregs CD4+CD25+T cells Phenotypic markers(FOXp3), CD103，GITR，TGF- β specifically regulate the activation, proliferation and effector function of activated conventional T cells Tregs’ suppressive function can be mediated by CTLA-4,TGF- β and IL-10 . Material and Methods Periodontal infection Quantification of alveolar bone loss Isolation of inflammatory cells from periodontal tissues and flow cytometric analysis Real-time polymerase chain reaction (PCR) reactions Protein extraction and cytokine ELISA Antibody and treatment Statistical analysis Experimental groups：an oral delivery o