h型高血压的流行病调查及叶酸、维生素b6联合甲钴胺干预效果研究.docVIP

精品论文 参考文献 H型高血压的流行病调查及叶酸、维生素B6联合甲钴胺干预效果研究 默军彩 　　（张家港市第六(锦丰)人民医院 江苏 苏州 215625） 　　【摘 要】目的：探讨H型高血压的流行病调查及叶酸、维生素B6联合甲钴胺的干预效果。方法：选择2011年10月至2013年2月我院收治的H型高血压患者136例，按照随机数字表法分为观察组和对照组，每组各68例。对照组给予安慰剂，观察组给予叶酸、维生素B6联合甲钴胺，对两组患者治疗前后的同型半胱氨酸的水平、脑卒中发生率及死亡率进行比较。结果：(1) 治疗后观察组的同型半胱氨酸的水平明显低于治疗前和对照组，具有显著性差异(Plt;0.05)。(2) 治疗后观察组的脑卒中发生率(4.4％)明显低于对照组(30.9％)，具有显著性差异(Plt;0.05)。结论：叶酸、维生素B6联合甲钴胺在治疗H型高血压中，可有效降低同型半胱氨酸的水平和脑卒中发生率，值得临床推广与应用。 　　【关键词】H型高血压；叶酸；维生素B6；甲钴胺 　　【中图分类号】R544.1 【文献标识码】A 【文章编号】1004-6194（2015）01-0150-01 　　Study on epidemiological investigation and intervention effect of 　　folic acid, vitamin B6 combined with mecobalaminin patients with H hypertension 　　【Abstract】Objective：To explore epidemiological investigation and intervention effect of folic acid, vitamin B6 combined with mecobalamin in patients with H hypertension. Methods：Totally 136 cases of patients with H hypertension in our hospital from October 2011 to February 2013 were randomly divided into observation group and control group, with 68 cases in each group. Control group was given placebo, while observation group was given folic acid, vitamin B6 combined with mecobalamin. Homocysteine, stroke incidence and mortality of patients in two groups were compared. Results：(1) Homocysteine of patients in observation group after treatment was significantly lower than before treatment and control group, the difference was statistically significant (Plt;0.05). (2) Stroke incidence of patients in observation group (4.4％) after treatment was significantly lower than that in control group (30.9％), the difference was statistically significant (Plt;0.05). Conclusion：Folic acid, vitamin B6 combined with mecobalamin in treatment of H hypertension can effectively reduce the level of homocysteine and stroke incidence. It is worthy of clinical application. 　　【Key words】H hypertension; folic acid; vitamin B6; mecobalamin 　　高血压是一种慢性终身性疾病，特别是对于老年患者而言，其严重影响了患者自身的生命及其家庭的生活质量，需要长期持续的进行治疗。而高血压人群中大多数患者的同型半胱氨酸(homocysteine，HCY) 的水平较高，将