nalp3炎性体与msu晶体及其在痛风发病中的作用.docVIP

精品论文 参考文献 Nalp3炎性体与MSU晶体及其在痛风发病中的作用 何琴花 王一飞(通讯作者) 张明 （上海中医药大学附属岳阳中西医结合医院痛风专科 上海 200437） 【摘要】 痛风作为一种代谢性疾病在我国发病率呈现逐年上升的趋势。目前，对痛风发病机制的研究进展有了很多新的认识和突破。NALP3炎性复合体与急性痛风性关节炎的关系日益受到重视和关注。单钠尿酸盐（monosodium urate，MSU）作为一个内源性危险信号，沉积于组织会激发强烈的炎症反应，并且能被模式识别受体识别，激活多个过程，最终导致NALP3炎性体的形成。NALP3炎性体作为一个多蛋白复合体，活化后可以介导半胱氨酸天冬氨酸蛋白酶-1（caspase-1）的激活，从而促进白细胞介素1β（IL-1β）前体转化为成熟的IL-1β，诱导痛风炎症的发生。现就有关NALP3炎性体的研究进展及其与MSU的相互作用在痛风发病过程中的机制进行综述。 【关键词】 痛风；炎性体；NALP3；单钠尿酸盐 【中图分类号】R593 【文献标识码】A 【文章编号】2095-1752（2015）31-0134-04 Nalp3 inflammasome with MSU crystals and their roles in Gout He Qinhua，Wang Yifei，Zhang Ming Gout Clinic,Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200437,China Corresponding author：Wang Yifei 【Abstract】As a kind of metabolic disease, incidence rate of Gout shows a trend of rising year by year in our country．At present, the research progress of the pathogenesis of gout has a lot of new understanding and breakthrough.The relationship between NALP3 Inflammasome with the acute gouty arthritis is becoming more and more attention and concern.Monosodium urate (MSU) as an endogenous danger signal, depositing on the organization can inspire intense inflammatory response, and can be recognized by pattern recognition receptors to activate multiple processes, the final result is the formation of the NALP3 Inflammasome. NALP3 Inflammasome as a multi-protein complex, can activate caspase-1 after activation , thus promoting the maturity of interleukin 1 beta (IL - 1 beta) ,inducing occurrence of gout inflammation. Now,we review the research progress of NALP3 inflammasome and its interaction with the MSU in the process of the pathogenesis of gout. 【key words】Gout；inflammasome；NALP3；MSU 近年来，随着人们生活水平的提高，饮食结构的改变，痛风及高尿酸血症的发病率逐年增高，已成为威胁人类健康的严重代谢性疾病。痛风多发于40岁以上的男性，女性则多数于绝经期后发病，